EGFR‐mediated signaling pathway influences the sensitivity of oral squamous cell carcinoma to JQ1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26920
Abstract: Inhibiting BRD4 has emerged as a promising anticancer strategy, and inhibitors such as JQ1 can suppress cell growth in oral squamous cell carcinoma (OSCC). However, the mechanism through which JQ1 exerts its anticancer activity has… read more here.
Keywords: cell; signaling pathway; jq1; mediated signaling ... See more keywords
Comparative Transcriptomic and Proteomic Analyses Reveal a FluG‐Mediated Signaling Pathway Relating to Asexual Sporulation of Antrodia camphorata
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201700256
Abstract: Medicinal mushroom Antrodia camphorata sporulate large numbers of arthroconidia in submerged fermentation, which is rarely reported in basidiomycetous fungi. Nevertheless, the molecular mechanisms underlying this asexual sporulation (conidiation) remain unclear. Here, we used comparative transcriptomic… read more here.
Keywords: sporulation; asexual sporulation; camphorata; flug mediated ... See more keywords
IFN-γ Mediated Signaling Improves Fungal Clearance in Experimental Pulmonary Mucormycosis
Sign Up to like & getrecommendations! Published in 2021 at "Mycopathologia"
DOI: 10.1007/s11046-021-00598-2
Abstract: We established three immunocompetent murine models of pulmonary mucormycosis to determine the involvement of the adaptive immune response in host resistance in pulmonary mucormycosis, a rapidly fatal disease caused mainly by Rhizopus spp. Immunocompetent inbred… read more here.
Keywords: mucormycosis; pulmonary mucormycosis; mice; ifn mediated ... See more keywords
Danshen modulates Nrf2-mediated signaling pathway in cisplatin-induced renal injury
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Science"
DOI: 10.1007/s11596-017-1801-1
Abstract: SummaryDanshen, an efficacious agent for cardiovascular diseases, has been found to play an essential role in kidney injury. In the present study, the effect of Danshen on cisplatin-induced renal dysfunction was investigated in a mouse… read more here.
Keywords: cisplatin; danshen; nrf2 mediated; induced renal ... See more keywords
APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.087
Abstract: Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer's disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are pathogenic, the APP holoprotein serves multiple purposes in the nervous system… read more here.
Keywords: app mediated; alzheimer disease; app; signaling prevents ... See more keywords
MiR-18a-downregulated RORA inhibits the proliferation and tumorigenesis of glioma using the TNF-α-mediated NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102651
Abstract: Background Glioma has a poor prognosis, and is the most common primary and lethal primary malignant tumor in the central nervous system. Retinoic acid receptor-related orphan receptor A (RORA) is a member of the ROR… read more here.
Keywords: glioma; tnf mediated; proliferation tumorigenesis; tumorigenesis glioma ... See more keywords
Low-concentration BPF induced cell biological responses by the ERα and GPER1-mediated signaling pathways in MCF-7 breast cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.08.102
Abstract: Bisphenol F (BPF), one of the alternatives to bisphenol A (BPA), can induce proliferation through the nuclear estrogen receptor ERα (estrogen receptor alpha) pathway in human breast cancer MCF-7 cells. However, the roles of membrane… read more here.
Keywords: signaling pathways; breast cancer; proliferation; mediated signaling ... See more keywords
Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.11.020
Abstract: ABSTRACT In diabetes, there are two major physiological aberrations: (i) Loss of insulin signaling due to absence of insulin (type 1 diabetes) or insulin resistance (type 2 diabetes) and (ii) increased blood glucose levels. The… read more here.
Keywords: insulin; signaling rpe; function; mediated signaling ... See more keywords
Identification of ecdysteroid receptor-mediated signaling pathways in the hepatopancreas of the red swamp crayfish, Procambarus clarkii.
Sign Up to like & getrecommendations! Published in 2017 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.01.013
Abstract: The hepatopancreas of crustaceans plays an important role in lipid and carbohydrate metabolism, digestion of food, and biogenesis. In this study, the hepatopancreas transcriptome from the red crayfish Procambarus clarkii was characterized for the first… read more here.
Keywords: signaling pathways; ecdysteroid receptor; procambarus clarkii; mediated signaling ... See more keywords
Gymnemic Acid Ameliorate Hyperglycemia Through PI3K/AKT and AMPK Mediated Signaling Pathway in T2DM Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b04931
Abstract: Gymnemic acid (GA) isolated from gymnema sylvestre (Retz.) Schult has been shown to display anti-diabetic activity, however the molecular mechanisms governing these effects are unclear. In this study, GA (40, 80 mg/kg/day) was evaluated by… read more here.
Keywords: gymnemic acid; akt ampk; pi3k akt; ampk mediated ... See more keywords
Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior
Sign Up to like & getrecommendations! Published in 2018 at "Molecular psychiatry"
DOI: 10.1038/mp.2016.218
Abstract: The bed nucleus of the stria terminalis (BNST) is a brain region important for regulating anxiety-related behavior in both humans and rodents. Here we used a chemogenetic strategy to investigate how engagement of G protein-coupled… read more here.
Keywords: like behavior; anxiety like; bnst vgat; mediated signaling ... See more keywords