Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing
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DOI: 10.1093/nar/gkad088
Abstract: Abstract In Bacteria, nucleoid structuring proteins govern nucleoid dynamics and regulate transcription. In Shigella spp., at ≤30°C, the histone-like nucleoid structuring protein (H-NS) transcriptionally silences many genes on the large virulence plasmid. Upon a switch… read more here.
Keywords: dna; virb; dna supercoiling; transcription ... See more keywords
Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution
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DOI: 10.1093/nar/gkw792
Abstract: Our current knowledge about the mechanisms of miRNA silencing is restricted to few lineages such as vertebrates, arthropods, nematodes and land plants. miRNA-mediated silencing in bilaterian animals is dependent on the proteins of the GW182… read more here.
Keywords: mediated silencing; conservation mirna; 600 million; mirna mediated ... See more keywords
Methylation Mediated Silencing of miR-155 Suppresses the Development of Preeclampsia In Vitro and In Vivo by Targeting FOXO3
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DOI: 10.1155/2022/4250621
Abstract: Preeclampsia (PE) is a common pregnancy-related syndrome characterized by chronic immune activation. This study is aimed at exploring the role of miR-155 in the inflammatory pathogenesis of PE. Placental tissues and peripheral blood were collected… read more here.
Keywords: mir 155; mediated silencing; silencing mir; methylation mediated ... See more keywords
Expression of Concern to: Lentivirus mediated silencing of Ubiquitin Specific Peptidase 39 inhibits cell proliferation of human hepatocellular carcinoma cells in vitro
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DOI: 10.1186/s40659-018-0170-y
Abstract: Concerns have been raised about this article [1] relating to the appropriateness of the use of the shRNA (5′-GCGGAGGGTTTGAAAGAATATCTCGAGATATTCTTTCAAACCCTCCGCTTTTTT-3′) as a non-targeting control and similarities in text and formatting with other published articles. This is… read more here.
Keywords: mediated silencing; lentivirus mediated; ubiquitin specific; concern lentivirus ... See more keywords
Uncovering Regulators of Heterochromatin Mediated Silencing Using a Zebrafish Transgenic Reporter
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DOI: 10.3389/fcell.2022.832461
Abstract: Heterochromatin formation and maintenance is critical for the repression of transcription from repetitive sequences. However, in vivo tools for monitoring heterochromatin mediated repression of repeats in the context of vertebrate development have been lacking. Here… read more here.
Keywords: reporter; uncovering regulators; mediated silencing; heterochromatin mediated ... See more keywords