Enzyme‐Mediated In Situ Self‐Assembly AIE Probes: Mapping the Distribution of Acetylcholinesterase in Aging Mice Brain
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DOI: 10.1002/adfm.202425074
Abstract: Acetylcholinesterase (AChE) exhibits profound association with the underlying pathological mechanisms of aging‐related disorders. However, revealing the spatial distribution of AChE among whole‐brain remains an uncharted territory, posing a substantial challenge. Herein, a dual regulation strategy… read more here.
Keywords: brain; distribution; acetylcholinesterase; ache ... See more keywords
Nanoparticle-Mediated In Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy.
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DOI: 10.1021/acsnano.1c04456
Abstract: Immune checkpoint blockade involves targeting immune regulatory molecules with antibodies. Preclinically, complex multiantibody regimes of both inhibitory and stimulatory targets are a promising candidate for the next generation of immunotherapy. However, in this setting, the… read more here.
Keywords: immune checkpoint; immunotherapy; mediated situ; checkpoint interactions ... See more keywords
Bacteria-mediated in situ polymerization of peptide-modified acrylamide for enhancing antimicrobial activity.
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DOI: 10.1039/d2cc03858g
Abstract: Bacteria-mediated reactions can utilize the natural activities of bacteria to produce bioactive products. Here, bacteria-mediated polymerization of the acrylamide-functionalized peptide Trp-Arg-Lys (Am-WRK) afforded an antibacterial polymer, PAm-WRK, which simulates the cationic and hydrophobic structures of… read more here.
Keywords: polymerization peptide; situ polymerization; mediated situ; bacteria mediated ... See more keywords
Nickel (II) Mediated In-situ Complex Formation with unexpected Ligand Transformations: Crystal Structures, DFT calculations and Catalytic Activity in CO2 Fixation Reaction
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DOI: 10.1039/d4nj01801j
Abstract: Two transformed ligands namely 1,3,5-triazapentadienato(imidoylamidinato) and N-(methoxy(pyrimidin-2-yl)(pyrimidine-2-carboxamido)methyl)pyrimidine-2-carboxamide which is the first report that are produced from 2-cyano pyridine/pyrimidine respectively under nickel metal mediation in presence of hydroxyl-amine hydrochloride in in-situ... read more here.
Keywords: situ complex; formation unexpected; unexpected ligand; complex formation ... See more keywords