Improved Synthesis of Phosphoramidite-Protected N6-Methyladenosine via BOP-Mediated SNAr Reaction
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules26010147
Abstract: N6-methyladenosine(m6A) is the most abundant modification in mRNA. Studies on proteins that introduce and bind m6A require the efficient synthesis of oligonucleotides containing m6A. We report an improved five-step synthesis of the m6A phosphoramidite starting… read more here.
Keywords: snar reaction; methyladenosine; mediated snar; phosphoramidite ... See more keywords