GPR56 S4 variant is required for microglia‐mediated synaptic pruning
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24293
Abstract: ADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not… read more here.
Keywords: synaptic pruning; microglia mediated; gpr56 variant; mediated synaptic ... See more keywords
Microglia modulate TNFα-mediated synaptic plasticity.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24383
Abstract: The pro-inflammatory cytokine tumor necrosis factor α (TNFα) tunes the capacity of neurons to express synaptic plasticity. It remains, however, unclear how TNFα mediates synaptic positive (=change) and negative (=stability) feedback mechanisms. We assessed effects… read more here.
Keywords: tnf; mediated synaptic; plasticity; tnf mediated ... See more keywords
Arc-Mediated Synaptic Plasticity Regulates Cognitive Function in a Migraine Mouse Model
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13020331
Abstract: Previous clinical and basic studies have shown that migraine is associated with cognitive impairment, anxiety, and depression. It severely affects the quality of life. In this study, C57BL/6 mice were randomly divided into four groups:… read more here.
Keywords: arc mediated; cognitive function; migraine; group ... See more keywords