Copper-Mediated Three-Component Reaction for the Synthesis of N-Acylsulfonamide on DNA.
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DOI: 10.1021/acs.orglett.2c01675
Abstract: The DNA-encoded library (DEL) technology is a new method for discovering hit compounds for target proteins in the pharmaceutical industry. The N-acylsulfonamide functional group has been reported to exhibit various pharmacological activities, and based on… read more here.
Keywords: copper; dna; mediated three; copper mediated ... See more keywords
Highly Reactive Palladium-Catalyzed and Acetonitrile-Mediated Three-Component Reactions for Arylsulfone Synthesis.
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DOI: 10.1021/acs.orglett.2c03430
Abstract: Arylsulfone groups play an important role in the synthesis of functionalized molecules. The acetonitrile-mediated three-component reactions for arylsulfone synthesis were developed in the presence of a 0.00025 mol % palladium catalyst. Arylboronic acids reacted with… read more here.
Keywords: component reactions; reactions arylsulfone; mediated three; synthesis ... See more keywords
Construction of 2-Arylbenzo[4,5]thieno[2,3-d]thiazole Skeleton via CuCl/S-Mediated Three-Component Reaction.
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DOI: 10.1021/acs.orglett.9b04206
Abstract: An exclusive thiophene-fused polycyclic π-conjugated 2-arylbenzo[4,5]thieno[2,3-d]thiazole skeleton was constructed via a one-pot CuCl-mediated three-component reaction, using 2-(2-bromophenyl)acetonitrile and aromatic aldehydes as substrates and elemental sulfur as sulfur source in the presence of K2CO3 and 1,10-phen… read more here.
Keywords: thiazole skeleton; mediated three; reaction; arylbenzo thieno ... See more keywords
Visible-Light-Mediated Three-Component Cascade Sulfonylative Annulation
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DOI: 10.1021/acsomega.2c02302
Abstract: Visible-light-promoted cascade radical cyclization for the synthesis of sulfonylated benzimidazo/indolo[2,1-a]iso-quinolin-6(5H)-ones has been reported. The reaction provides transition-metal-free and expeditious access to sulfonylated polyaromatics. The use of sodium metabisulfite as a SO2 surrogate and the rapid… read more here.
Keywords: mediated three; component cascade; three component; visible light ... See more keywords