PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120149119
Abstract: Significance A variety of mechanisms safeguard the body from autoimmune reactions, yet how these processes cooperate is largely unclear. Using a range of mouse genetic models, we uncover a critical tolerogenic axis between the autoimmune… read more here.
Keywords: lethal autoimmune; cooperates aire; mediated tolerance; tolerance prevent ... See more keywords
Type 1 regulatory T cell-mediated tolerance in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032575
Abstract: Type 1 regulatory T (Tr1) cells, in addition to other regulatory cells, contribute to immunological tolerance to prevent autoimmunity and excessive inflammation. Tr1 cells arise in the periphery upon antigen stimulation in the presence of… read more here.
Keywords: tr1; disease; mediated tolerance; tr1 cells ... See more keywords