Unraveling GLUT‐mediated transcytosis pathway of glycosylated nanodisks
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DOI: 10.1016/j.ajps.2020.07.001
Abstract: Glucose transporter (GLUT)-mediated transcytosis has been validated as an efficient method to cross the blood-brain barrier and enhance brain transport of nanomedicines. However, the transcytosis process remains elusive. Glycopeptide-modified nanodisks (Gly-A7R-NDs), which demonstrated high capacity… read more here.
Keywords: gly a7r; glut mediated; glut; mediated transcytosis ... See more keywords
Pathways of protein and lipid receptor-mediated transcytosis in drug delivery
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DOI: 10.1080/17425247.2016.1220364
Abstract: ABSTRACT Introduction: A critical factor for the efficacy of drugs is their availability at the site of interest. However, crossing endothelial and epithelial cell layers like the blood-brain barrier and the blood-intestinal barrier represents a… read more here.
Keywords: drug; drug delivery; mediated transcytosis; receptor mediated ... See more keywords
Treatment of Neuronopathic Mucopolysaccharidoses with Blood–Brain Barrier-Crossing Enzymes: Clinical Application of Receptor-Mediated Transcytosis
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DOI: 10.3390/pharmaceutics14061240
Abstract: Enzyme replacement therapy (ERT) has paved the way for treating the somatic symptoms of lysosomal storage diseases (LSDs), but the inability of intravenously administered enzymes to cross the blood–brain barrier (BBB) has left the central… read more here.
Keywords: mediated transcytosis; receptor mediated; neuronopathic mucopolysaccharidoses; blood brain ... See more keywords
Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation
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DOI: 10.3390/pharmaceutics15041268
Abstract: Currently, many neurological disorders lack effective treatment options due to biological barriers that effectively separate the central nervous system (CNS) from the periphery. CNS homeostasis is maintained by a highly selective exchange of molecules, with… read more here.
Keywords: mediated transcytosis; receptor mediated; transcytosis; regulation ... See more keywords