Dynamics of IRES-mediated translation
Sign Up to like & getrecommendations! Published in 2017 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0177
Abstract: Viral internal ribosome entry sites (IRESs) are unique RNA elements, which use stable and dynamic RNA structures to recruit ribosomes and drive protein synthesis. IRESs overcome the high complexity of the canonical eukaryotic translation initiation… read more here.
Keywords: ires mediated; iress; initiation; translation ... See more keywords
Drug Screening for Hepatitis A Virus (HAV): Nicotinamide Inhibits c-Jun Expression and HAV Replication
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01987-22
Abstract: Drug screening methods targeting HAV IRES-mediated translation with reporter assays are attractive and useful for drug repurposing. Nicotinamide (vitamin B3, niacin) has been shown to effectively inhibit HAV replication. ABSTRACT Hepatitis A virus (HAV) infection… read more here.
Keywords: mediated translation; ires mediated; replication; hav replication ... See more keywords
MYC-Mediated Translation of PD-L1 Promotes Liver Cancer Immune Escape.
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DOI: 10.1158/2159-8290.cd-rw2019-011
Abstract: MYC and KRASG12D exhibit distinct roles in the post-transcriptional regulation of immune checkpoints. read more here.
Keywords: translation promotes; mediated translation; myc mediated; cancer ... See more keywords
Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development
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DOI: 10.3390/biomedicines10081865
Abstract: Many conditions can benefit from RNA-based therapies, namely, those targeting internal ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors (ITAFs). IRES-mediated translation is an alternative mechanism of translation initiation, known for… read more here.
Keywords: mediated translation; ires mediated; ribosome entry; development ... See more keywords
Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells
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DOI: 10.3390/cancers12082169
Abstract: The eukaryotic translation initiation factor 4F complex (eIF4F) is a potential chemotherapeutic target in triple-negative breast cancer (TNBC). This complex regulates cap-dependent translational initiation and consists of three core proteins: eIF4E, eIF4G, and eIF4A1. In… read more here.
Keywords: eif4a1 mediated; cardiac glycosides; inhibitors eif4a1; translation ... See more keywords