Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation
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DOI: 10.1038/s41598-018-21873-1
Abstract: Hypertension and aneurysm are frequently associated with autosomal dominant polycystic kidney disease (ADPKD) caused by polycystin-1 (PC1) mutations, which is closely related to endothelial dysfunction. PC1 is an atypical G-protein-coupled receptor that activates G-proteins by… read more here.
Keywords: pc1; endothelial function; trpc4 activation; mediated trpc4 ... See more keywords