Bioengineered tissue models for the development of dynamic immuno-associated tumor models and high-throughput immunotherapy cytotoxicity assays.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.11.028
Abstract: Cancer immunotherapy is rapidly developing, with numerous therapies approved over the past decade and more therapies expected to gain approval in the future. However, immunotherapy of solid tumors has been less successful because immunosuppressive barriers… read more here.
Keywords: mediated tumor; immunotherapy; tumor models; cancer ... See more keywords
Arsenic Prodrug-Mediated Tumor Microenvironment Modulation Platform for Synergetic Glioblastoma Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c12076
Abstract: Glioblastoma (GBM) has a distinct internal environment characterized by high levels of glutathione (GSH) and low oxygen partial pressure, which significantly restrict most drugs' effectiveness. Arsenic-based drugs are emerging candidates for treating solid tumors; however,… read more here.
Keywords: mediated tumor; glioblastoma; arsenic prodrug; therapy ... See more keywords
Iodine Conjugated Pt(IV) Nanoparticles for Precise Chemotherapy with Iodine-Pt Guided Computed Tomography Imaging and Biotin-Mediated Tumor-Targeting.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c01764
Abstract: Theranostics of platinum (Pt)-based chemotherapy are able to self-track the biodistribution and pharmacokinetics while performing therapeutic effects. Pt-based CT imaging is expected to visualize and monitor the tumor throughout the entire tumor inhibition stage. However,… read more here.
Keywords: iodine; mediated tumor; biotin mediated; tumor ... See more keywords
Deconstructing networks of p53-mediated tumor suppression in vivo
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DOI: 10.1038/cdd.2017.171
Abstract: The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses including oncogene activation, DNA damage, hypoxia and nutrient deprivation, p53 activates a panoply of target genes and orchestrates numerous downstream responses… read more here.
Keywords: mediated tumor; p53 mediated; tumor suppression; p53 ... See more keywords
SIRPĪ±-CD47 Blockade-Mediated Tumor Cell Phagocytosis Requires SLAMF7.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-081
Abstract: SLAMF7 expression is required for macrophage-mediated phagocytosis of hematopoietic tumor cells. read more here.
Keywords: mediated tumor; phagocytosis; blockade mediated; cd47 blockade ... See more keywords
Molecular Characteristics of T Cell-Mediated Tumor Killing in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.868480
Abstract: Background Although checkpoint blockade is a promising approach for the treatment of hepatocellular carcinoma (HCC), subsets of patients expected to show a response have not been established. As T cell-mediated tumor killing (TTK) is the… read more here.
Keywords: mediated tumor; hepatocellular carcinoma; tumor killing; tumor ... See more keywords