Plasma Protein-Mediated Uptake and Contradictions to the Free Drug Hypothesis: A Critical Review.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2195133
Abstract: According to the free drug hypothesis (FDH), only free, unbound drug is available to interact with biological targets. This hypothesis is the fundamental principle that continues to explain the vast majority of all pharmacokinetic and… read more here.
Keywords: plasma protein; protein mediated; drug hypothesis; mediated uptake ... See more keywords
Effect of molecular weight on sonoporation-mediated uptake in human cardiac cells
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DOI: 10.1121/1.4989211
Abstract: Sonoporation of cells induced by ultrasound-driven microbubble cavitation has been utilized for intracellular delivery of molecular therapeutics. The molecular weight of therapeutic agents can vary significantly, with DNA plasmids often larger than 5 MDa, siRNAs… read more here.
Keywords: mediated uptake; sonoporation mediated; sonoporation; molecular weight ... See more keywords
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody
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DOI: 10.1186/s13550-018-0358-8
Abstract: BackgroundIdeally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development. However, the imaging signal consists of specific, as… read more here.
Keywords: mediated uptake; immuno pet; antibody; anti cd44 ... See more keywords
Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids
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DOI: 10.3389/fphar.2020.00802
Abstract: Enalaprilat is the active metabolite of enalapril, a widely used antihypertension drug. The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of… read more here.
Keywords: uptake enalaprilat; mediated uptake; inhibition oat3; drug ... See more keywords