PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin
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DOI: 10.1182/bloodadvances.2021006730
Abstract: Key Points • PUM1, an RNA-binding protein, is a novel target of EKLF that binds to fetal γ-globin mRNA and impairs its stability and translation.• Elevated HbF levels are observed upon PUM1 knockdown ex vivo… read more here.
Keywords: mediates posttranscriptional; human fetal; posttranscriptional regulation; pum1 mediates ... See more keywords