Characterization of Mediator Complex and its Associated Proteins from Rice.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7125-1_9
Abstract: The Mediator complex is a multi-protein complex that acts as a molecular bridge conveying transcriptional messages from the cis element-bound transcription factor to the RNA Polymerase II machinery. It is found in all eukaryotes including… read more here.
Keywords: mediator; associated proteins; complex associated; characterization mediator ... See more keywords
Therapeutic potential of Mediator complex subunits in metabolic diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2017.10.012
Abstract: The multisubunit Mediator is an evolutionary conserved transcriptional coregulatory complex in eukaryotes. It is needed for the transcriptional regulation of gene expression in general as well as in a gene specific manner. Mediator complex subunits… read more here.
Keywords: transcription; mediator; metabolic diseases; mediator complex ... See more keywords
The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.06.052
Abstract: Mediator is a large protein complex required for basal and regulated expression of most RNA polymerase II (RNAP II)-transcribed genes, in part due to its interaction with and phosphorylation of the conserved C-terminal domain (CTD)… read more here.
Keywords: mediator; tetrahymena thermophila; mediator complex; regulation ... See more keywords
Induced pluripotent stem cells (SHCDNi002-A cells) isolated from the peripheral blood mononuclear cells of a 1-year-old Chinese girl with mediator complex subunit 12-related syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101838
Abstract: Mediator complex subunit 12 (MED12)-related disorders are recessive-X-linked intellectual disabilities present primarily in male patients. We came across a female patient with a heterozygous mutation (c.1249-1G > C) related to MED12-related syndrome. MED12 expression was significantly lower… read more here.
Keywords: related syndrome; complex subunit; mediator complex; pluripotent stem ... See more keywords
Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates with Evolutionarily Novel Subunits
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00368
Abstract: The eukaryotic Mediator is a large and conserved multisubunit protein complex that directly contacts RNA polymerase II and impinges on multiple aspects of gene expression. The genome of the human malaria parasite Plasmodium falciparum has… read more here.
Keywords: plasmodium falciparum; malaria parasite; mediator complex; mediator ... See more keywords
The role of the Mediator complex in fungal pathogenesis and response to antifungal agents.
Sign Up to like & getrecommendations! Published in 2023 at "Essays in biochemistry"
DOI: 10.1042/ebc20220238
Abstract: Mediator is a complex of polypeptides that plays a central role in the recruitment of RNA polymerase II to promoters and subsequent transcriptional activation in eukaryotic organisms. Studies have now shown that Mediator has a… read more here.
Keywords: role; mediator complex; role mediator; complex fungal ... See more keywords
Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse†, ‡
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy004
Abstract: Abstract Understanding factors that regulate zygotic genome activation (ZGA) is critical for determining how cells are reprogrammed to become totipotent or pluripotent. There is limited information regarding how this process occurs physiologically in early mammalian… read more here.
Keywords: genome activation; zygotic genome; med13; mediator complex ... See more keywords
The plant Mediator complex and its role in jasmonate signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erz233
Abstract: Abstract The Mediator complex is an essential, multisubunit transcriptional coactivator that is highly conserved in eukaryotes. Mediator interacts with gene-specific transcription factors, the RNA polymerase II transcriptional machinery, as well as several other factors involved… read more here.
Keywords: jasmonate signaling; plant; mediator; plant mediator ... See more keywords
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1289
Abstract: Abstract Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, by using genome-wide CRISPR–Cas9… read more here.
Keywords: med13; cyclin; resistance; mediator complex ... See more keywords
The power of the Mediator complex—Expanding the genetic architecture and phenotypic spectrum of MED12‐related disorders
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Genetics"
DOI: 10.1111/cge.13412
Abstract: MED12 is a member of the large Mediator complex that controls cell growth, development, and differentiation. Mutations in MED12 disrupt neuronal gene expression and lead to at least three distinct X‐linked intellectual disability syndromes (FG,… read more here.
Keywords: architecture phenotypic; phenotypic; med12; mediator complex ... See more keywords
Identification of Therapeutic Targets and Prognostic Biomarkers among Genes from the Mediator Complex Family in the Hepatocellular Carcinoma Tumour-Immune Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/2021613
Abstract: Background Hepatocellular carcinoma (HCC) is predominant among all types of primary liver cancers characterised by high morbidity and mortality. Genes in the mediator complex (MED) family are engaged in the tumour-immune microenvironment and function as… read more here.
Keywords: hepatocellular carcinoma; family; mediator complex; tumour immune ... See more keywords