Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.11.013
Abstract: Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on… read more here.
Keywords: mediator kinase; phosphorylation; jak stat; phosphorylation stat1 ... See more keywords
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer
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DOI: 10.1038/s41388-018-0316-y
Abstract: CDK8 is a transcription-regulating kinase that controls TGF-β/BMP-responsive SMAD transcriptional activation and turnover through YAP1 recruitment. However, how the CDK8/YAP1 pathway influences SMAD1 response in cancer remains unclear. Here we report that SMAD1-driven epithelial-to-mesenchymal transition… read more here.
Keywords: mediator kinase; cdk19; cdk8; cancer ... See more keywords
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00171
Abstract: CDK8 and its paralog, CDK19, collectively termed ‘Mediator Kinase,’ are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner,… read more here.
Keywords: mediator kinase; mediator; kinase; cdk8 cdk19 ... See more keywords