CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment.
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DOI: 10.1182/blood-2017-06-791103
Abstract: To the editor: Germ line–activating mutations of protein tyrosine phosphatase PTPN11 (Shp2), a positive regulator of the Ras signaling pathway,[1][1] account for more than 50% of patients with Noonan syndrome.[2][2] These patients have an increased… read more here.
Keywords: ptpn11; ccl3 key; activating mutations; key mediator ... See more keywords