The 2016 Frontiers in Medicinal Chemistry Conference in Bonn
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DOI: 10.1002/cmdc.201600639
Abstract: Pushing the frontiers of medicinal chemistry: Christa Müller, Dominik Thimm, and Karl-Heinz Baringhaus look back at the events of the 2016 Frontiers in Medicinal Chemistry (FiMC) Conference held in Bonn, Germany. The report highlights the… read more here.
Keywords: 2016 frontiers; chemistry conference; medicinal chemistry; chemistry ... See more keywords
Diversity in Medicinal Chemistry
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DOI: 10.1002/cmdc.201700803
Abstract: The wide world of medicinal chemistry: We look back at our activities in 2017, particularly the expansion of the journal's scope to nanomedicine and why we need a more inclusive medicinal chemistry journal. Additionally, we… read more here.
Keywords: medicinal chemistry; chemistry; diversity medicinal;
Development of Fibrates as Important Scaffolds in Medicinal Chemistry
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DOI: 10.1002/cmdc.201900128
Abstract: Fibrates are a class of phenoxyisobutyric acid derivatives mainly used as anti‐hyperlipidemic agents. The fibrate scaffold has undergone a variety of chemical modifications, providing a wide spectrum of biological activities. Within the last few years,… read more here.
Keywords: development fibrates; fibrates important; important scaffolds; medicinal chemistry ... See more keywords
Recent Highlights in Anti‐infective Medicinal Chemistry from South Africa
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DOI: 10.1002/cmdc.202000086
Abstract: Global advancements in biological technologies have vastly increased the variety of and accessibility to bioassay platforms, while simultaneously improving our understanding of druggable chemical space. In the South African context, this has resulted in a… read more here.
Keywords: infective medicinal; highlights anti; medicinal chemistry; chemistry ... See more keywords
Med Chem Remote: The Frontiers in Medicinal Chemistry 2021
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DOI: 10.1002/cmdc.202100355
Abstract: Digital, but delicious! The Frontiers in Medicinal Chemistry 2021 meeting, originally intended to take place in Darmstadt, carried on as an online event from March 8-10 this year. Even with pandemic restrictions, the event co-presented… read more here.
Keywords: chem remote; medicinal chemistry; chemistry; med chem ... See more keywords
Clickable Selenylation – a Paradigm for Seleno‐Medicinal Chemistry
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DOI: 10.1002/cmdc.202200324
Abstract: Selenium (Se) is an emerging versatile player in medicinal chemistry. The incorporation of Se into small molecules and natural products could have multiple benefits. However, the lack of efficient methods for the synthesis of Se‐containing… read more here.
Keywords: clickable selenylation; medicinal chemistry; development; chemistry ... See more keywords
Frontiers in Medicinal Chemistry 2022 Goes Virtual
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DOI: 10.1002/cmdc.202200419
Abstract: The Frontiers in Medicinal Chemistry (FiMC) meeting, which represents the largest international medicinal chemistry conference in Germany, took place from March 14th to 16th 2022 in a fully virtual format. Organized by the Division of… read more here.
Keywords: frontiers medicinal; medicinal chemistry; chemistry; 2022 goes ... See more keywords
An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society **
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DOI: 10.1002/cmdc.202300014
Abstract: The Division of Medicinal Chemistry and Chemical Biology (DMCCB) of the Swiss Chemical Society is an active contributor to the dynamics of the Swiss and European scientific communities. Founded in 1987, it pursues its mission… read more here.
Keywords: chemical biology; medicinal chemistry; chemistry; chemistry chemical ... See more keywords
Integrated design environment: A multi‐use platform for design idea capture, evaluation, and tracking in medicinal chemistry
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DOI: 10.1002/jcc.27041
Abstract: An integrated design environment (IDE) has been developed that allows the capture of design ideas, virtual compounds, and design hypotheses for medicinal chemistry projects. Specific consideration for rational molecular design, including design strategy and tactics,… read more here.
Keywords: medicinal chemistry; design environment; chemistry; integrated design ... See more keywords
Medicinal chemistry strategies toward host targeting antiviral agents
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DOI: 10.1002/med.21664
Abstract: Abstract Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic. However, DAAs suffer from several inherent limitations, including… read more here.
Keywords: medicinal chemistry; chemistry; viral infections; antiviral agents ... See more keywords
Unconventional amino acids in medicinal chemistry: First report on taurine merged within carbonic anhydrase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104236
Abstract: This study reports the design, synthesis of a series of taurine containing benzenesulfonamide derivatives which were all screened in vitro against the physiological relevant human (h) expressed Carbonic Anhydrase (CA; EC 4.2.1.1) I, II, IX,… read more here.
Keywords: unconventional amino; carbonic anhydrase; medicinal chemistry; chemistry ... See more keywords