Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction
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DOI: 10.1016/j.bpj.2020.04.026
Abstract: Medin, a 50-amino-acid cleavage product of the milk fat globule-EGF factor 8 protein, is one of the most common forms of localized amyloid found in the vasculature of individuals older than 50 years. Medin induces… read more here.
Keywords: microscopy; medin; pore formation; pathology ... See more keywords
Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization
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DOI: 10.1111/acel.13746
Abstract: Vascular amyloidosis, caused when peptide monomers aggregate into insoluble amyloid, is a prevalent age‐associated pathology. Aortic medial amyloid (AMA) is the most common human amyloid and is composed of medin, a 50‐amino acid peptide. Emerging… read more here.
Keywords: ecm; cell; aggregation; senescence ... See more keywords