Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01146-6
Abstract: Reduced activity of the mediodorsal thalamus (MD) and abnormal functional connectivity of the MD with the prefrontal cortex (PFC) cause cognitive deficits in schizophrenia. However, the molecular basis of MD hypofunction in schizophrenia is not… read more here.
Keywords: schizophrenia associated; synaptic function; schizophrenia; mediodorsal thalamus ... See more keywords
Mediodorsal Thalamus Is Critical for Updating during Extradimensional Shifts But Not Reversals in the Attentional Set-Shifting Task
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0162-21.2022
Abstract: Abstract Cognitive flexibility, attributed to frontal cortex, is vital for navigating the complexities of everyday life. The mediodorsal thalamus (MD), interconnected to frontal cortex, may influence cognitive flexibility. Here, male rats performed an attentional set-shifting… read more here.
Keywords: extradimensional shifts; mediodorsal thalamus; shifting task; choice ... See more keywords
Ultrastructural and Functional Properties of a Giant Synapse Driving the Piriform Cortex to Mediodorsal Thalamus Projection
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2017.00003
Abstract: Neocortico-thalamo-cortical loops represent a common, yet poorly understood, circuit employing giant synapses also referred to as “class I”, giant, or driver synapses. Here, we characterize a giant synapse formed by projection neurons of the paleocortical… read more here.
Keywords: functional properties; piriform cortex; giant synapse; mediodorsal thalamus ... See more keywords
Mediodorsal thalamus is required for discrete phases of goal-directed behavior in macaques
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.37325
Abstract: Reward contingencies are dynamic: outcomes that were valued at one point may subsequently lose value. Action selection in the face of dynamic reward associations requires several cognitive processes: registering a change in value of the… read more here.
Keywords: action selection; discrete phases; value; mediodorsal thalamus ... See more keywords