Construction of an engineered biocatalyst system for the production of medium-chain α,ω-dicarboxylic acids from medium-chain ω-hydroxycarboxylic acids.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27433
Abstract: Medium-chain α,ω-dicarboxylic acids produced from renewable long-chain fatty acids are valuable as precursors in the chemical industry. However, they are difficult to produce biologically at high concentrations. Although improved biocatalyst systems, consisting of engineering of… read more here.
Keywords: chain; production; biocatalyst; medium chain ... See more keywords
Stairway to Stereoisomers: Engineering Short‐ and Medium‐Chain Ketoreductases To Produce Chiral Alcohols
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200687
Abstract: The short‐ and medium‐chain dehydrogenase/reductase superfamilies are responsible for most chiral alcohol production in laboratories and industries. In nature, they participate in diverse roles such as detoxification, housekeeping, secondary metabolite production, and catalysis of several… read more here.
Keywords: short medium; engineering short; engineering; medium chain ... See more keywords
Discovery and identification of medium‐chain fatty acid responsive promoters in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2020 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201900093
Abstract: Medium‐chain fatty acids (MCFAs) and their derivatives are important chemicals that can be used in lubricants, detergents, and cosmetics. MCFAs can be produced in several microbes, although production is not high. Dynamic regulation by synthetic… read more here.
Keywords: saccharomyces cerevisiae; fatty acid; responsive promoters; medium chain ... See more keywords
Epilepsy and inborn errors of metabolism in adults: The diagnostic odyssey of a young woman with medium‐chain acyl‐coenzyme A dehydrogenase deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12630
Abstract: We describe a case of epileptic encephalopathy in a young woman with undiagnosed medium‐chain acyl‐coenzyme A dehydrogenase deficiency (MCADD), who presented with an early‐onset focal motor status epilepticus (SE) then followed by permanent left hemiplegia… read more here.
Keywords: young woman; etiology; acyl coenzyme; chain acyl ... See more keywords
Nonclinical safety and pharmacokinetics of Miglyol 812: A medium chain triglyceride in exenatide once weekly suspension
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3640
Abstract: Exenatide, a glucagon‐like peptide‐1 receptor agonist was originally developed as either a twice daily or once weekly injectable therapeutic for patients with type 2 diabetes. Exenatide QW suspension was developed for use with an autoinjector… read more here.
Keywords: medium chain; miglyol 812; safety; toxicology ... See more keywords
Medium‐Chain Triglycerides Supplementation Protects Epilepsy‐Associated Behavioral Impairments in a Mouse Model
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70213
Abstract: Presently there has been a growing interest in the development of dietary‐based interventions as alternative therapies to combat chronic neurological conditions like epilepsy. Medium‐chain triglycerides (MCT) are composed of three fatty acids attached to a… read more here.
Keywords: supplementation; medium chain; chain triglycerides; mct supplementation ... See more keywords
Plasma lipidomics analysis reveals altered profile of triglycerides and phospholipids in children with Medium‐Chain Acyl‐CoA dehydrogenase deficiency
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12718
Abstract: Medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) is the most prevalent mitochondrial fatty acid β‐oxidation disorder. In this study, we assessed the variability of the lipid profile in MCADD by analysing plasma samples obtained from 25 children… read more here.
Keywords: medium chain; analysis; acyl coa; chain acyl ... See more keywords
Dietary medium-chain 1-monoglycerides modulates the community and function of cecal microbiota of broilers.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11562
Abstract: BACKGROUND Medium-chain monoglycerides (MG) are a group of 1-monoglycerides of medium-chain fatty acids with strong antibacterial activity, which may influence the gut microbiota in the diet of broilers. The present study evaluated the effects of… read more here.
Keywords: chain; microbiota; community; medium chain ... See more keywords
Acidolysis of Phospholipids with Medium-Chain Fatty Acids over M-SBA-15 (M = Zn, Al) Silicas as Efficient Solid Catalysts.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11832
Abstract: Efficient and sustainable production of structured phospholipids (SPLs) enriched in medium-chain fatty acids (MCFAs) in a heterogeneous manner is crucial for their potential applications in functional foods and drugs. Herein, for the first time, Zn… read more here.
Keywords: chain fatty; spectroscopy; sba silicas; fatty acids ... See more keywords
Acute and chronic effects of oral administration of a medium‐chain fatty acid, capric acid, on locomotor activity and anxiety‐like and depression‐related behaviors in adult male C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12226
Abstract: Capric acid (also known as decanoic acid or C10) is one of the fatty acids in the medium‐chain triglycerides (MCTs) commonly found in dietary fats. Although dietary treatment with MCTs is recently of great interest… read more here.
Keywords: medium chain; effects oral; oral administration; capric acid ... See more keywords
Development of a fast and cost-effective gas chromatography–mass spectrometry method for the quantification of short-chain and medium-chain fatty acids in human biofluids
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0493-5
Abstract: The quantification of short-chain and medium-chain fatty acids is becoming more and more relevant in fecal and plasma samples due to their biological impact, which has been associated with colon rectal cancer and fiber consumption.… read more here.
Keywords: chain; method; medium chain; short chain ... See more keywords