Design and Synthesis of Conformationally Diverse Pyrimidine-Embedded Medium/Macro- and Bridged Cycles via Skeletal Transformation
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DOI: 10.3389/fchem.2022.841250
Abstract: The rigidity and flexibility of small molecules are complementary in 3-dimensional ligand-protein interaction. Therefore, the chemical library with conformational diversity would be a valuable resource for investigating the influence of skeletal flexibility on the biological… read more here.
Keywords: medium macro; diverse pyrimidine; embedded medium; conformationally diverse ... See more keywords