Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05284-2
Abstract: RationaleJuvenile social isolation (SI) and neglect is associated with a wide range of psychiatric disorders. While dysfunction of the corticolimbic pathway is considered to link various abnormal behaviors in SI models of schizophrenia, the enduring… read more here.
Keywords: enduring effects; social isolation; spiny neurons; physiological properties ... See more keywords
Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.08.106
Abstract: Huntington's disease (HD) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular functions that is dysregulated in HD is store-operated calcium entry (SOCE), a process… read more here.
Keywords: yac128 mice; huntington disease; spiny neurons; disease ... See more keywords
Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107829
Abstract: Medium spiny neurons (MSNs) of mice show opposing activities upon the initiation of a food-seeking lever press task. Ventromedial striatal (VMS)-MSNs are inhibited but ventrolateral striatal (VLS)-MSNs are activated; these activities mediate action selection and… read more here.
Keywords: expressing interneurons; striatal parvalbumin; parvalbumin expressing; medium spiny ... See more keywords
Human cellular models of medium spiny neuron development and Huntington disease
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.07.030
Abstract: ABSTRACT The loss of gamma‐aminobutyric acid (GABA)‐ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. Transplantation of… read more here.
Keywords: huntington disease; differentiation; medium spiny; stem cells ... See more keywords
Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.03.010
Abstract: The mechanisms of dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) remain unclear, although it is known that the nucleus accumbens (NAc) plays a role in its development. Based on the hypothesis that DDS and… read more here.
Keywords: dendritic spine; spiny neurons; nucleus accumbens; medium spiny ... See more keywords
High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107773
Abstract: Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have been implicated in the release of dopamine from the ventral… read more here.
Keywords: glycine receptors; medium spiny; spiny neurons; nucleus accumbens ... See more keywords
Nicotine-induced and D1-receptor-dependent dendritic remodeling in a subset of dorsolateral striatum medium spiny neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.036
Abstract: Nicotine is one of the most addictive substances known, targeting multiple memory systems, including the ventral and dorsal striatum. One form of neuroplasticity commonly associated with nicotine is dendrite remodeling. Nicotine-induced dendritic remodeling of ventral… read more here.
Keywords: nicotine; nicotine induced; spiny neurons; striatum ... See more keywords
Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0332-9
Abstract: Dopaminergic modulation of corticostriatal transmission is critically involved in reward-driven behaviors. This modulation is mainly mediated by dopamine D1 receptors (D1Rs) and D2Rs, which are highly expressed in medium spiny neurons (MSNs) of the dorsomedial… read more here.
Keywords: transmission; glutamatergic transmission; receptor; expressing afferents ... See more keywords
Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44798-9
Abstract: Subcellular RNAseq promises to dissect transcriptional dynamics but is not well characterized. Furthermore, FACS may introduce bias but has not been benchmarked genome-wide. Finally, D1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the… read more here.
Keywords: spiny neurons; biology; nucleus accumbens; medium spiny ... See more keywords
Long‐term subregion‐specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12526
Abstract: The nucleus accumbens (NAc) is a critical component of the mesocorticolimbic system and is involved in mediating the motivational and reinforcing aspects of ethanol consumption. Chronic intermittent ethanol (CIE) exposure is a reliable model to… read more here.
Keywords: long term; nac shell; medium spiny; spiny neurons ... See more keywords
Selective block of adenosine A2A receptors prevents ischaemic‐like effects induced by oxygen and glucose deprivation in rat medium spiny neurons
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15922
Abstract: Ischaemia is known to cause massive neuronal depolarization, termed anoxic depolarization (AD), due to energy failure and loss of membrane ion gradients. The neuromodulator adenosine accumulates extracellularly during ischaemia and activates four metabotropic receptors: A1,… read more here.
Keywords: a2a receptors; block adenosine; spiny neurons; medium spiny ... See more keywords