Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2018.09.005
Abstract: Renal medullary carcinoma (RMC) is one of the most aggressive renal cell carcinomas. It predominantly afflicts young adults and adolescents with sickle cell trait and other sickle hemoglobinopathies, and is refractory to targeted and antiangiogenic… read more here.
Keywords: management clinical; carcinoma; diagnosis management; medullary carcinoma ... See more keywords
Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2016.12.013
Abstract: Colorectal medullary carcinoma, recognized by the World Health Organization as a distinct histologic subtype, is commonly regarded as a specific entity with an improved prognosis and unique molecular pathogenesis. A fundamental but as yet unaddressed… read more here.
Keywords: carcinoma; colorectal medullary; group; medullary carcinoma ... See more keywords
Next Generation Sequencing of Renal Medullary Carcinoma Diagnosed Concurrently with Sickle Cell Trait: A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.164
Abstract: We present a 33-year-old African American male with 4 months of intermittent right flank pain and gross hematuria with hypermetabolic retroperitoneal lymphadenopathy, persistent right-sided hydronephrosis, perinephric fat stranding and a 5.5-cm hypermetabolic right lower pole… read more here.
Keywords: cell trait; renal medullary; sickle cell; medullary carcinoma ... See more keywords
Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.1101/2022.04.28.489873
Abstract: Renal medullary carcinoma (RMC) is a highly aggressive disease associated with sickle hemoglobinopathies and universal loss of the tumor suppressor gene SMARCB1. RMC has a relatively low rate of incidence compared with other renal cell… read more here.
Keywords: medullary carcinoma; renal medullary; tumor microenvironment; tumor ... See more keywords
IgM paraprotein and anti-MAG sensory polyneuropathy associated with Waldenstrom’s macroglobulinaemia and medullary carcinoma of the thyroid
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-240242
Abstract: A previously fit and well 76-year-old man, presented with distal lower limb sensory symptoms suggestive of peripheral sensory neuropathy, associated with positive anti-MAG antibodies (myelin associated glycoprotein) and IgM paraprotein. Bone marrow biopsy showed lymphoplasmocytoid… read more here.
Keywords: igm paraprotein; sensory; medullary carcinoma; waldenstrom macroglobulinaemia ... See more keywords
Pancreatic medullary carcinoma developed on a pancreatic intraductal papillary mucinous neoplasm with loss of MSH2 and MSH6 expression: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostic Pathology"
DOI: 10.1186/s13000-021-01178-0
Abstract: Background Pancreatic medullary carcinoma (PMC) is a rare pancreatic tumor, usually showing the presence of microsatellite instability, mostly MLH1 silencing, and a wild-type KRAS mutation status. We report here a PMC arising from a Pancreatic… read more here.
Keywords: msh2 msh6; medullary carcinoma; carcinoma; loss msh2 ... See more keywords
Predictive role of PD-L1 expression in the response of renal Medullary carcinoma to PD-1 inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1186/s40425-017-0267-9
Abstract: BackgroundRenal medullary carcinoma is one of the rarest malignancies arising from the kidney. Despite various aggressive therapeutic regimens, mortality remains significantly high (95%) with a median overall survival of 5Â months. Furthermore, the scarcity of this… read more here.
Keywords: response; predictive role; medullary carcinoma; renal medullary ... See more keywords
Medullary carcinoma of the duodenum treated with pembrolizumab: a case report
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-755
Abstract: Background Medullary carcinoma (MC) is a recognized histologic subtype of colorectal cancer characterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate. However, MC originating from the small intestine is exceedingly rare, with only nine cases… read more here.
Keywords: duodenum; medullary carcinoma; treated pembrolizumab; report ... See more keywords
SMARCB1 regulates a TFCP2L1-MYC transcriptional switch promoting renal medullary carcinoma transformation and ferroptosis resistance
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.21203/rs.3.rs-1178801/v1
Abstract: Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin and oncogenic mechanism remain poorly understood. Using single-cell sequencing of human… read more here.
Keywords: medullary carcinoma; ferroptosis resistance; renal medullary; ferroptosis ... See more keywords
Recent Advances in Renal Medullary Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137097
Abstract: Renal medullary carcinoma (RMC) is a rare renal malignancy that has been associated with sickle hemoglobinopathies. RMC is aggressive, difficult to treat, and occurs primarily in adolescents and young adults of African ancestry. This cancer… read more here.
Keywords: medullary carcinoma; advances renal; renal medullary; biology ... See more keywords