BRAF Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11091252
Abstract: Colorectal rhabdoid carcinomas (CRbCs) are very rare and aggressive cancers. The BRAF mutation and CpG island methylator phenotype have been reported to be common features of CRbCs. This study reviews the literature about CRbCs and… read more here.
Keywords: poorly differentiated; medullary carcinomas; colorectal rhabdoid; braf mutation ... See more keywords
Renal Medullary Carcinomas Harbor a Distinct Methylation Phenotype and Display Aberrant Methylation of Genes Related to Early Nephrogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205044
Abstract: Simple Summary Renal medullary carcinomas (RMC) are aggressive tumors of the kidneys, characterized by a loss of SMARCB1. As the tumors, arising predominantly in young males with sickle cell trait, are very rare and no… read more here.
Keywords: methylation; renal medullary; nephrogenesis; medullary carcinomas ... See more keywords
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.44161
Abstract: Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful patient-derived RMC models and using whole-genome sequencing, we identified loss-of-function intronic… read more here.
Keywords: smarcb1 loss; loss; carcinomas depend; renal medullary ... See more keywords