AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5777
Abstract: Despite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by… read more here.
Keywords: thymic epithelial; tcs; aire illuminates; epithelial cells ... See more keywords
Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.121
Abstract: The sole nonredundant role of the thymic medulla is to induce central tolerance, a vital process that depends on promiscuous gene expression (pGE), a unique feature of medullary thymic epithelial cells (mTECs). Although pGE enhances… read more here.
Keywords: homeostasis; epithelial cells; mtecs; proteotoxic stress ... See more keywords
A novel method to efficiently isolate medullary thymic epithelial cells from murine thymi based on UEA-1 MicroBeads.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2019.02.001
Abstract: OBJECTIVE The central mechanism for establishing a self-tolerant and functional T cell repertoire includes the promiscuous expression of otherwise tissue-restricted proteins by medullary thymic epithelial cells (TEC). We here demonstrate a novel and highly efficient… read more here.
Keywords: epithelial cells; uea microbeads; thymic epithelial; cell ... See more keywords
Epithelial LTβR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44481
Abstract: The establishment of T cell central tolerance critically relies on the development and maintenance of the medullary thymic epithelial cells (mTECs). Disrupted signaling of lymphotoxin beta receptor (LTβR) results in dramatically reduced mTEC population. However,… read more here.
Keywords: epithelial cells; size; thymic epithelial; epithelial signaling ... See more keywords
Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00964
Abstract: The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which is crucial for the negative selection of autoreactive thymocytes in the thymus. This process represents the root of central tolerance of… read more here.
Keywords: mtec thymocyte; thymocyte adhesion; aire; adhesion ... See more keywords
Aire Gene Influences the Length of the 3′ UTR of mRNAs in Medullary Thymic Epithelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01039
Abstract: Aire is a transcriptional controller in medullary thymic epithelial cells (mTECs) modulating a set of peripheral tissue antigens (PTAs) and non-PTA mRNAs as well as miRNAs. Even miRNAs exerting posttranscriptional control of mRNAs in mTECs,… read more here.
Keywords: epithelial cells; aire; mtecs; aire gene ... See more keywords
Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.948259
Abstract: The expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs) is believed to be responsible for the elimination of autoreactive T cells, a critical process in the maintenance of central immune tolerance. The… read more here.
Keywords: thymic epithelial; autoimmune diseases; tsas; epithelial cells ... See more keywords
Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.60188
Abstract: Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific antigens (TSAs). Recent… read more here.
Keywords: expression; development; thymic epithelial; cell ... See more keywords