MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA
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DOI: 10.1093/neuonc/noy059.501
Abstract: BACKGROUND The MYC oncogenes contribute to more than 50% of all human cancers, but their therapeutic targeting has proven challenging. MYC/MYCN amplification in childhood medulloblastoma (MB) and neuroblastoma (NB) determine aggressive disease and high mortality,… read more here.
Keywords: medulloblastoma neuroblastoma; myc mycn; mycn amplified; adaptation myc ... See more keywords