MiR‐199a‐3p inhibition facilitates cardiomyocyte differentiation of embryonic stem cell through promotion of MEF2C
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28899
Abstract: MicroRNAs (miRNAs) is a small molecule (19–25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR‐199a‐3p has… read more here.
Keywords: stem cell; mir 199a; mef2c; differentiation ... See more keywords
LncRNA UCA1 Suppresses the Inflammation Via Modulating miR-203-Mediated Regulation of MEF2C/NF-κB Signaling Pathway in Epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02952-9
Abstract: Although many advances have been made in the pathogenesis of epilepsy recently, the pathological mechanisms of epilepsy are still largely unknown. Exploring the pathological mechanisms and developing novel therapeutic strategies for epilepsy are urgently needed.… read more here.
Keywords: mir 203; mef2c; expression; lncrna uca1 ... See more keywords
MiR-448 promotes vascular smooth muscle cell proliferation and migration in through directly targeting MEF2C
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-9771-1
Abstract: Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a critical process in various cardiovascular diseases such as coronary artery disease (CAD), atherosclerosis, stroke, and hypertension. MicroRNAs (miRNAs) are small, short, and noncoding… read more here.
Keywords: proliferation migration; mef2c; proliferation; mir 448 ... See more keywords
Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and Connectivity of Cerebellar Purkinje Cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1363-7
Abstract: Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability. Although perturbations in the cerebellum, notably Purkinje cells, have been linked to these neurological disorders, the underlying mechanisms remain poorly understood.… read more here.
Keywords: mef2c expression; purkinje cells; mef2c; cerebellar purkinje ... See more keywords
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.11.032
Abstract: Background A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. Alternative splicing of MEF2C exons α, β and γ provides transcript diversity with gene… read more here.
Keywords: mef2c; cell cycle; heart failure;
CAIII expression in skeletal muscle is regulated by Ca2+-CaMKII-MEF2C signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111672
Abstract: Carbonic anhydrase III (CAIII) is selectively expressed in slow-twitch myofibers in skeletal muscle. The fast-twitch to slow-twitch transformation of myofibers following denervation is accompanied by increased CAIII expression, suggesting that the effects of nerve impulses… read more here.
Keywords: skeletal muscle; caiii expression; expression; mef2c ... See more keywords
Identification of the Regulatory Elements and Target Genes of Megakaryopoietic Transcription Factor MEF2C.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1678694
Abstract: Megakaryopoiesis produces specialized haematopoietic stem cells in the bone marrow that give rise to megakaryocytes which ultimately produce platelets. Defects in megakaryopoiesis can result in altered platelet counts and physiology, leading to dysfunctional haemostasis and… read more here.
Keywords: transcription; mef2c; target genes; megakaryopoiesis ... See more keywords
A neuronal enhancer network upstream of MEF2C is compromised in patients with Rett-like characteristics
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy393
Abstract: Abstract Mutations in myocyte enhancer factor 2C (MEF2C), an important transcription factor in neurodevelopment, are associated with a Rett‐like syndrome. Structural variants (SVs) upstream of MEF2C, which do not disrupt the gene itself, have also… read more here.
Keywords: mef2c; network; rett like; neuronal enhancer ... See more keywords
LKB1-Salt-Inducible Kinase Signaling Is Essential in MEF2C+ Leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-044
Abstract: MEF2C activity in acute myeloid leukemia is dependent upon salt-inducible kinase (SIK) signaling. read more here.
Keywords: leukemia; inducible kinase; mef2c; salt inducible ... See more keywords
MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.150363
Abstract: Rearrangements that drive ectopic MEF2C expression have recurrently been found in patients with human early thymocyte progenitor acute lymphoblastic leukemia (ETP-ALL). Here, we show high levels of MEF2C expression in patients with ETP-ALL. Using both… read more here.
Keywords: notch lymphoid; opposes notch; mef2c opposes; mef2c expression ... See more keywords
Comprehensive Analysis of Immunophenotype and Transcriptome in Indian T-Acute Lymphoblastic Leukemia - a Prospective Study
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-127980
Abstract: T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive hematologic tumors that result from the malignant transformation of T-cell progenitors. T-ALLs are classified immunologically into immature (pro- and pre-T), cortical and mature T-ALL. ETP-ALL is a recently… read more here.
Keywords: baalc; mef2c; ipt; expression ... See more keywords