Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and Connectivity of Cerebellar Purkinje Cells
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DOI: 10.1007/s12035-018-1363-7
Abstract: Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability. Although perturbations in the cerebellum, notably Purkinje cells, have been linked to these neurological disorders, the underlying mechanisms remain poorly understood.… read more here.
Keywords: mef2c expression; purkinje cells; mef2c; cerebellar purkinje ... See more keywords
MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.150363
Abstract: Rearrangements that drive ectopic MEF2C expression have recurrently been found in patients with human early thymocyte progenitor acute lymphoblastic leukemia (ETP-ALL). Here, we show high levels of MEF2C expression in patients with ETP-ALL. Using both… read more here.
Keywords: notch lymphoid; opposes notch; mef2c opposes; mef2c expression ... See more keywords