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Published in 2019 at "Cancer"
DOI: 10.1002/cncr.31961
Abstract: I read with interest the recent report by Maraka et al, which described the results of a phase 1 study of temozolomide together with combinations of repurposed memantine, metformin, and mefloquine for the treatment of…
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Keywords:
treatment;
study;
drug;
neuropsychiatric adverse ... See more keywords
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Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1250-y
Abstract: Mefloquine was retrieved as a glucagon -like peptide-1 receptor agonist and, therefore, evaluated for its antidiabetic potential against non-insulin-dependent diabetes mellitus (NIDDM) in experimental animals. NIDDM was induced by single intraperitoneal injection of streptozotocin and…
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Keywords:
antidiabetic activity;
albino wistar;
receptor;
wistar rats ... See more keywords
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Published in 2017 at "Travel medicine and infectious disease"
DOI: 10.1016/j.tmaid.2017.10.011
Abstract: BACKGROUND Mefloquine is recommended in international health guidelines for preventing malaria in travellers. Reports of psychosis and suicide are often alluded to but are not clearly established. METHODS We carried out a systematic review of…
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Keywords:
systematic review;
associated mefloquine;
mefloquine;
deaths parasuicides ... See more keywords
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Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00003
Abstract: Malaria remains a worldwide concern in terms of morbidity and mortality. Limited understanding of the Plasmodium proteome makes it challenging to control malaria. Understanding of the expression and functions of different Plasmodium proteins will help…
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Keywords:
acyl coa;
mefloquine;
coa binding;
pfacbps ... See more keywords
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Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2019.1607371
Abstract: Abstract Malaria is a global public health problem that causes approximately 445 000 deaths annually worldwide, especially in underdeveloped countries. Because of the high prevalence and mortality of the disease, new and less toxic therapeutic…
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Keywords:
malaria;
hybrid salt;
safety;
artesunate mefloquine ... See more keywords
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Published in 2018 at "Behavioral Medicine"
DOI: 10.1080/08964289.2017.1330497
Abstract: In his response to our article, Remington Nevin argues that mefloquine exposure is an important confounder and that our failure to control for this variable invalidates our combat exposure model of post-traumatic stress disorder (PTSD).…
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Keywords:
post traumatic;
stress disorder;
exposure;
traumatic stress ... See more keywords
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Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13764
Abstract: To predict the optimal chemoprophylactic dose of mefloquine in infants of 5–10 kg using physiologically based pharmacokinetic (PBPK) and clinical effectiveness models.
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Keywords:
based pharmacokinetic;
clinical effectiveness;
physiologically based;
model ... See more keywords
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Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282099
Abstract: Background Declining in susceptibility of Plasmodium falciparum to mefloquine is reported in South-East Asia. A revisiting on mefloquine pharmacokinetics-pharmacodynamics (PK/PD) could assist in finding new appropriate dosage regimens in combination with artesunate as a three-day…
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Keywords:
mefloquine sensitive;
mefloquine;
ic50;
combination ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165167
Abstract: The development of novel pharmaceutical tools to efficiently tackle tuberculosis is the order of the day due to the rapid development of resistant strains of Mycobacterium tuberculosis. Herein, we report novel potential formulations of a…
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Keywords:
mycobacterium tuberculosis;
mflh;
vitro activity;
organic salts ... See more keywords
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Published in 2022 at "Viruses"
DOI: 10.3390/v14020374
Abstract: Despite the development of specific therapies against severe acute respiratory coronavirus 2 (SARS-CoV-2), the continuous investigation of the mechanism of action of clinically approved drugs could provide new information on the druggable steps of virus–host…
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Keywords:
sars cov;
chloroquine mefloquine;
mefloquine;
mefloquine inhibits ... See more keywords