Unexpectedly low rates of neuropsychiatric adverse effects associated with mefloquine repurposed for the treatment of glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.31961
Abstract: I read with interest the recent report by Maraka et al, which described the results of a phase 1 study of temozolomide together with combinations of repurposed memantine, metformin, and mefloquine for the treatment of… read more here.
Keywords: treatment; study; drug; neuropsychiatric adverse ... See more keywords
Antidiabetic activity of mefloquine via GLP-1 receptor modulation against STZ–NA-induced diabetes in albino wistar rats
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1250-y
Abstract: Mefloquine was retrieved as a glucagon -like peptide-1 receptor agonist and, therefore, evaluated for its antidiabetic potential against non-insulin-dependent diabetes mellitus (NIDDM) in experimental animals. NIDDM was induced by single intraperitoneal injection of streptozotocin and… read more here.
Keywords: antidiabetic activity; albino wistar; receptor; wistar rats ... See more keywords
Deaths and parasuicides associated with mefloquine chemoprophylaxis: A systematic review.
Sign Up to like & getrecommendations! Published in 2017 at "Travel medicine and infectious disease"
DOI: 10.1016/j.tmaid.2017.10.011
Abstract: BACKGROUND Mefloquine is recommended in international health guidelines for preventing malaria in travellers. Reports of psychosis and suicide are often alluded to but are not clearly established. METHODS We carried out a systematic review of… read more here.
Keywords: systematic review; associated mefloquine; mefloquine; deaths parasuicides ... See more keywords
Characterization of Lipid Binding Properties of Plasmodium falciparum Acyl-Coenzyme A Binding Proteins and Their Competitive Inhibition by Mefloquine.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00003
Abstract: Malaria remains a worldwide concern in terms of morbidity and mortality. Limited understanding of the Plasmodium proteome makes it challenging to control malaria. Understanding of the expression and functions of different Plasmodium proteins will help… read more here.
Keywords: acyl coa; mefloquine; coa binding; pfacbps ... See more keywords
Safety assessment of MEFAS: an innovative hybrid salt of mefloquine and artesunate for malaria treatment
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2019.1607371
Abstract: Abstract Malaria is a global public health problem that causes approximately 445 000 deaths annually worldwide, especially in underdeveloped countries. Because of the high prevalence and mortality of the disease, new and less toxic therapeutic… read more here.
Keywords: malaria; hybrid salt; safety; artesunate mefloquine ... See more keywords
Response to Letter to the Editor: Confounding by Symptomatic Mefloquine Exposure in Military Studies of Post-Traumatic Stress Disorder
Sign Up to like & getrecommendations! Published in 2018 at "Behavioral Medicine"
DOI: 10.1080/08964289.2017.1330497
Abstract: In his response to our article, Remington Nevin argues that mefloquine exposure is an important confounder and that our failure to control for this variable invalidates our combat exposure model of post-traumatic stress disorder (PTSD).… read more here.
Keywords: post traumatic; stress disorder; exposure; traumatic stress ... See more keywords
Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13764
Abstract: To predict the optimal chemoprophylactic dose of mefloquine in infants of 5–10 kg using physiologically based pharmacokinetic (PBPK) and clinical effectiveness models. read more here.
Keywords: based pharmacokinetic; clinical effectiveness; physiologically based; model ... See more keywords
Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
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DOI: 10.1371/journal.pone.0282099
Abstract: Background Declining in susceptibility of Plasmodium falciparum to mefloquine is reported in South-East Asia. A revisiting on mefloquine pharmacokinetics-pharmacodynamics (PK/PD) could assist in finding new appropriate dosage regimens in combination with artesunate as a three-day… read more here.
Keywords: mefloquine sensitive; mefloquine; ic50; combination ... See more keywords
Novel Organic Salts Based on Mefloquine: Synthesis, Solubility, Permeability, and In Vitro Activity against Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165167
Abstract: The development of novel pharmaceutical tools to efficiently tackle tuberculosis is the order of the day due to the rapid development of resistant strains of Mycobacterium tuberculosis. Herein, we report novel potential formulations of a… read more here.
Keywords: mycobacterium tuberculosis; mflh; vitro activity; organic salts ... See more keywords
Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020374
Abstract: Despite the development of specific therapies against severe acute respiratory coronavirus 2 (SARS-CoV-2), the continuous investigation of the mechanism of action of clinically approved drugs could provide new information on the druggable steps of virus–host… read more here.
Keywords: sars cov; chloroquine mefloquine; mefloquine; mefloquine inhibits ... See more keywords