Monocyte secretory profiling in a clinical and MEFV genotype-characterized cohort of Danish familial Mediterranean fever patients: diagnostic potential of CCL1 and CXCL1.
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Rheumatology"
DOI: 10.1080/03009742.2022.2028382
Abstract: Objective The autoinflammatory disease familial Mediterranean fever (FMF), characterized by recurrent attacks of sterile fever, serosal, and/or synovial inflammation, is caused by variants in the Mediterranean fever gene, MEFV, coding for the pyrin inflammasome sensor.… read more here.
Keywords: fmf patients; fmf; mefv; mediterranean fever ... See more keywords
M694I variant of MEFV drives pathogenesis of familial Mediterranean fever through enhanced Th17 cell differentiation.
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf336
Abstract: OBJECTIVE To investigate how the M694I variant of MEFV contributes to familial Mediterranean fever (FMF) pathophysiology using knock-in mice, focusing on T helper 17 (Th17) cell responses and the underlying molecular mechanisms. METHODS Human MEFV… read more here.
Keywords: differentiation; m694i; th17; cell ... See more keywords