Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.
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DOI: 10.1053/j.gastro.2017.11.276
Abstract: BACKGROUND & AIMS Inflammatory bowel diseases (IBD) increase risk for colorectal cancer. Mutations in the Mediterranean fever gene (MEFV or pyrin) are associated with hereditary autoinflammatory disease and severe IBD. Expression of MEFV, a sensor protein… read more here.
Keywords: tumorigenesis; control mice; mefv mice; colon ... See more keywords