Megakaryocyte-stromal cell interactions: effect on megakaryocyte proliferation, proplatelet production, and survival.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental hematology"
DOI: 10.1016/j.exphem.2022.01.002
Abstract: Bone marrow stromal cells provide a proper environment for the development of hematologic lineages. The incorporation of different stromal cells to in vitro culture systems would be an attractive model to study megakaryopoiesis and thrombopoiesis. Our… read more here.
Keywords: survival; megakaryocyte; stromal cell; mks ... See more keywords
Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte-Erythroid Progenitors.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2018.4206
Abstract: Nd1-S is the nuclear-localizing short variant form of Nd1 (Ivns1abp) encoding a Kelch family transcription factor. While the function of Nd1 has been investigated in the context of metastasis and doxorubicin-induced cardiotoxicity, little is known… read more here.
Keywords: variant form; megakaryocyte dysplasia; megakaryocyte; erythroid megakaryocyte ... See more keywords
The pathobiology of platelet and megakaryocyte extracellular vesicles: A (c)lot has changed
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15750
Abstract: Platelet‐derived extracellular vesicles (PEVs) were originally studied for their potential as regulators of coagulation, a function redundant with that of their parent cells. However, as the understanding of the diverse roles of platelets in hemostasis… read more here.
Keywords: extracellular vesicles; megakaryocyte; pathology; pevs mkevs ... See more keywords
Antiplatelet antibody‐induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12678
Abstract: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by increased peripheral immune platelet destruction and megakaryocyte defects in the bone marrow. Although ITP was originally thought to be primarily due to antibody‐mediated autoimmunity, it… read more here.
Keywords: antiplatelet; antibody; megakaryocyte; immune thrombocytopenia ... See more keywords
The Value of Combined Detection of Megakaryocyte and Platelet Parameters for the Diagnosis of Primary Immune Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/10760296221106779
Abstract: Objective:To investigate the application value of bone marrow megakaryocyte count, the proportion of megakaryocytes at each stage, and the platelet parameter in the clinical diagnosis of primary immune thrombocytopenia (ITP). Methods: The megakaryocyte and platelet… read more here.
Keywords: primary immune; megakaryocyte; diagnosis primary; value ... See more keywords
Fetal versus adult megakaryopoiesis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2020009301
Abstract: Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared to adult progenitors, and generate large numbers of small, low ploidy megakaryocytes. Historically, these developmental differences were interpreted as "immaturity". However, more recent studies demonstrated that the… read more here.
Keywords: megakaryocyte; megakaryopoiesis; adult; versus adult ... See more keywords