Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver
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DOI: 10.1182/bloodadvances.2021005977
Abstract: Key Points Loss of Tgfb1 expression in MKs increases MK production in BM and TPO expression in the liver. Inhibition of TGF-β1 might increase MK generation in vivo and in vitro. read more here.
Keywords: tgf inhibits; megakaryocyte platelet; production; inhibits megakaryopoiesis ... See more keywords
The Analysis of the Human Megakaryocyte and Platelet Coding Transcriptome in Healthy and Diseased Subjects
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DOI: 10.3390/ijms23147647
Abstract: Platelets are generated and released into the bloodstream from their precursor cells, megakaryocytes that reside in the bone marrow. Though platelets have no nucleus or DNA, they contain a full transcriptome that, during platelet formation,… read more here.
Keywords: megakaryocyte platelet; rna seq; coding transcriptome; platelet ... See more keywords