Ex vivo manufacture of megakaryocytes and platelets from stem cells: recent advances towards transfusion in humans.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2020.0185
Abstract: The generation of ex vivo functional megakaryocytes and platelets is an important issue in transfusion medicine as donor-dependence implies in limitations, such as shortage of eligible volunteers. Indeed, platelet transfusion is still a procedure that… read more here.
Keywords: megakaryocytes platelets; platelets stem; transfusion; vivo manufacture ... See more keywords
Megakaryocytes and platelets embrace diversity in face of adversity
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DOI: 10.1111/jth.15761
Abstract: Platelets patrol blood vessels where they play an essential role in hemostasis and act as early responders to microbial threats. Billions of them are produced by megakaryocytes (MKs) each day. While the bone marrow was… read more here.
Keywords: sepsis; megakaryocytes platelets; face adversity; diversity face ... See more keywords
A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260286
Abstract: Platelets are found only in mammals. Uniquely, they have a log Gaussian volume distribution and are produced from megakaryocytes, large cells that have polyploid nuclei. In this Hypothesis, we propose that a possible explanation for… read more here.
Keywords: cell; change; evolutionary change; megakaryocytes platelets ... See more keywords
Transcription factors in megakaryocytes and platelets
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1140501
Abstract: Transcription factors bind promoter or regulatory sequences of a gene to regulate its rate of transcription. However, they are also detected in anucleated platelets. The transcription factors RUNX1, GATA1, STAT3, NFκB, and PPAR have been… read more here.
Keywords: platelets transcription; transcription; megakaryocytes platelets; transcription factors ... See more keywords