Ormeloxifene, a nonsteroidal antifertility drug promotes megakaryocyte differentiation in leukemia cell line K562.
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DOI: 10.1002/cbin.12017
Abstract: Ormeloxifene (ORM) (3,4-trans-2,2-dimethyl-3-phenyl-4-p-(β-pyrrolidinoethoxy) phenyl-7-methoxychroman), world's first nonsteroidal selective estrogen receptor modulator approved for contraception in India has been shown to have potential anticancer activities. Here, we show that ORM can induce megakaryocyte and myeloid (granulocytic) but not… read more here.
Keywords: leukemia cell; megakaryocytic differentiation; cell line; orm ... See more keywords
SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia
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DOI: 10.1038/s41417-020-00262-9
Abstract: A high incidence of acute megakaryoblastic leukemia (AMKL) in Down syndrome patients implies that chromosome 21 genes have a pivotal role in AMKL development, but the functional contribution of individual genes remains elusive. Here, we… read more here.
Keywords: gene expression; son; expression; megakaryocytic differentiation ... See more keywords
USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin
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DOI: 10.1111/bjh.16549
Abstract: Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is driven by complex genetic and epigenetic alterations from an aberrant clone of hematopoietic stem/progenitor cells (HSPCs). Ubiquitin‐specific protease 7 (USP7) has been demonstrated to have an… read more here.
Keywords: megakaryocytic differentiation; inhibition; proliferation; mds ... See more keywords