3031 – AN OLD CELL WITH NEW TRICKS: ALTERATIONS TO MEGAKARYOPOIESIS DURING AGING
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.051
Abstract: Our goal is to define the cellular and molecular mechanisms that control aging of the hematopoietic system. Given the increasing global life expectancy of people and the prevalence of age-related hematological diseases, understanding alterations to… read more here.
Keywords: mkps; megakaryopoiesis; old mkps; cell ... See more keywords
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07671-y
Abstract: Platelet homeostasis is essential for vascular integrity and immune defence1,2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the… read more here.
Keywords: homeostasis; cells control; plasmacytoid dendritic; dendritic cells ... See more keywords
Identification of the Regulatory Elements and Target Genes of Megakaryopoietic Transcription Factor MEF2C.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1678694
Abstract: Megakaryopoiesis produces specialized haematopoietic stem cells in the bone marrow that give rise to megakaryocytes which ultimately produce platelets. Defects in megakaryopoiesis can result in altered platelet counts and physiology, leading to dysfunctional haemostasis and… read more here.
Keywords: transcription; mef2c; target genes; megakaryopoiesis ... See more keywords
DNA damage repair in megakaryopoiesis: molecular and clinical aspects
Sign Up to like & getrecommendations! Published in 2024 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2024.2391102
Abstract: ABSTRACT Introduction Endogenous DNA damage is a significant factor in the damage of hematopoietic cells. Megakaryopoiesis is one of the pathways of hematopoiesis that ends with the production of platelets and plays the most crucial… read more here.
Keywords: dna damage; repair; dna repair; megakaryopoiesis ... See more keywords
Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/9258937
Abstract: Environmental chronic stress (ECS) has been identified as a trigger of acute coronary syndromes (ACS). Changes in redox balance, enhanced reactive oxygen species (ROS) production, and platelet hyperreactivity were detected in both ECS and ACS.… read more here.
Keywords: chronic stress; megakaryopoiesis; stress; apocynin ... See more keywords
MRTFA Augments Megakaryocyte Maturation By Enhancing the SRF Regulatory Axis
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118954
Abstract: Pediatric non-Down Syndrome acute megakaryoblastic leukemia (AMKL), a disease where megakaryocyte (MK) maturation is blocked, has a very poor prognosis. In 13% of AMKL cases of this type, the transcriptional co-factor MRTFA is expressed as… read more here.
Keywords: srf mrtfa; megakaryopoiesis; tpa induction; mrtfa ... See more keywords
Tropomyosin 1 Genetically Constrains in Vitro Megakaryopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-121538
Abstract: Platelet size and count are heritable, quantifiable outcomes of hematopoiesis. A better understanding of genetic mechanisms that regulate hematopoiesis could yield insights into blood disorders and augment clinical translational efforts to generate platelets in vitro.… read more here.
Keywords: loci; hematopoiesis; megakaryopoiesis; biology ... See more keywords
Concomitant Occurrence of Polyclonal Hematopoiesis and Cell-Autonomous Megakaryopoiesis in Triple-Negative Essential Thrombocythemia
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-134494
Abstract: Somatic mutations in JAK2, MPL, and CALR are found in approximately 80% of patients with essential thrombocythemia (ET), whereas the remaining patients are negative for disease-defining mutations and are defined as triple-negative (TN). Studies have… read more here.
Keywords: hematopoiesis; megakaryopoiesis; ltd; japan ... See more keywords
Acute CCL5 Exposure Promotes Megakaryopoiesis through Non-Canonical Pathways
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-207027
Abstract: Background: Despite the importance of platelets in thrombosis and hemostasis, the mechanism by which megakaryocytes (MKs) differentiate and initiate platelet release is incompletely understood. Although thrombopoietin (TPO) has been identified as the most important regulator… read more here.
Keywords: bone marrow; megakaryopoiesis; ccl5; platelet ... See more keywords
Fetal versus adult megakaryopoiesis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2020009301
Abstract: Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared to adult progenitors, and generate large numbers of small, low ploidy megakaryocytes. Historically, these developmental differences were interpreted as "immaturity". However, more recent studies demonstrated that the… read more here.
Keywords: megakaryocyte; megakaryopoiesis; adult; versus adult ... See more keywords
The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21030967
Abstract: Megakaryopoiesis is the process during which megakaryoblasts differentiate to polyploid megakaryocytes that can subsequently shed thousands of platelets in the circulation. Megakaryocytes accumulate mRNA during their maturation, which is required for the correct spatio-temporal production… read more here.
Keywords: protein; megakaryopoiesis; rna binding; gene expression ... See more keywords