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Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.051
Abstract: Our goal is to define the cellular and molecular mechanisms that control aging of the hematopoietic system. Given the increasing global life expectancy of people and the prevalence of age-related hematological diseases, understanding alterations to…
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Keywords:
mkps;
megakaryopoiesis;
old mkps;
cell ... See more keywords
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Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1678694
Abstract: Megakaryopoiesis produces specialized haematopoietic stem cells in the bone marrow that give rise to megakaryocytes which ultimately produce platelets. Defects in megakaryopoiesis can result in altered platelet counts and physiology, leading to dysfunctional haemostasis and…
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Keywords:
transcription;
mef2c;
target genes;
megakaryopoiesis ... See more keywords
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Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/9258937
Abstract: Environmental chronic stress (ECS) has been identified as a trigger of acute coronary syndromes (ACS). Changes in redox balance, enhanced reactive oxygen species (ROS) production, and platelet hyperreactivity were detected in both ECS and ACS.…
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Keywords:
chronic stress;
megakaryopoiesis;
stress;
apocynin ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118954
Abstract: Pediatric non-Down Syndrome acute megakaryoblastic leukemia (AMKL), a disease where megakaryocyte (MK) maturation is blocked, has a very poor prognosis. In 13% of AMKL cases of this type, the transcriptional co-factor MRTFA is expressed as…
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Keywords:
srf mrtfa;
megakaryopoiesis;
tpa induction;
mrtfa ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-121538
Abstract: Platelet size and count are heritable, quantifiable outcomes of hematopoiesis. A better understanding of genetic mechanisms that regulate hematopoiesis could yield insights into blood disorders and augment clinical translational efforts to generate platelets in vitro.…
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Keywords:
loci;
hematopoiesis;
megakaryopoiesis;
biology ... See more keywords
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Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-134494
Abstract: Somatic mutations in JAK2, MPL, and CALR are found in approximately 80% of patients with essential thrombocythemia (ET), whereas the remaining patients are negative for disease-defining mutations and are defined as triple-negative (TN). Studies have…
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Keywords:
hematopoiesis;
megakaryopoiesis;
ltd;
japan ... See more keywords
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Published in 2022 at "Blood"
DOI: 10.1182/blood.2020009301
Abstract: Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared to adult progenitors, and generate large numbers of small, low ploidy megakaryocytes. Historically, these developmental differences were interpreted as "immaturity". However, more recent studies demonstrated that the…
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Keywords:
megakaryocyte;
megakaryopoiesis;
adult;
versus adult ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21030967
Abstract: Megakaryopoiesis is the process during which megakaryoblasts differentiate to polyploid megakaryocytes that can subsequently shed thousands of platelets in the circulation. Megakaryocytes accumulate mRNA during their maturation, which is required for the correct spatio-temporal production…
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Keywords:
protein;
megakaryopoiesis;
rna binding;
gene expression ... See more keywords