Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Kidney International"
DOI: 10.1016/j.kint.2020.02.021
Abstract: Donnai-Barrow syndrome (DBS) is an autosomal-recessive disorder characterized by multiple pathologies including malformation of forebrain and eyes, as well as resorption defects of the kidney proximal tubule. The underlying cause of DBS are mutations in… read more here.
Keywords: barrow syndrome; megalin; donnai barrow; induced pluripotent ... See more keywords
Megalin: A Bridge Connecting Kidney, the Renin-angiotensin System, and Atherosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104537
Abstract: Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects… read more here.
Keywords: system; renin angiotensin; megalin; angiotensin system ... See more keywords
Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38613-8
Abstract: Serum 1,25(OH)2D and 24,25(OH)2D are decreased in CKD. Megalin in proximal tubular epithelial cells reabsorbs glomerular-filtered 25(OH)D-DBP complex to convert 25(OH)D to 1,25(OH)2D and 24,25(OH)2D. Urinary C-megalin excretion is increased via exocytosis from injured nephrons… read more here.
Keywords: vitamin metabolism; megalin excretion; urinary megalin; megalin ... See more keywords
The effect of cholesterol overload on mouse kidney and kidney-derived cells
Sign Up to like & getrecommendations! Published in 2018 at "Renal Failure"
DOI: 10.1080/0886022x.2017.1419974
Abstract: Abstract Introduction: Dyslipidemia is one of the onset and risk factors of chronic kidney disease and renal function drop is seen in lipoprotein abnormal animal models. However, the detailed molecular mechanism of renal lipotoxicity has… read more here.
Keywords: kidney derived; cholesterol overload; cholesterol; megalin ... See more keywords
Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-12-0811
Abstract: Megalin (gp330, LRP-2) is a protein structurally related to the low-density lipoprotein receptor family that displays a large luminal domain with multiligand binding properties. Megalin localizes to the apical surface of multiple epithelia, where it… read more here.
Keywords: clathrin clathrin; megalin biosynthetic; trafficking; megalin ... See more keywords
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0510
Abstract: The kidney proximal tubule (PT) elaborates a uniquely high capacity apical endocytic pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier. Megalin and cubilin/amnionless (CUBAM) receptors engage Dab2 in these cells… read more here.
Keywords: megalin; megalin cubilin; endocytic pathway; dab2 ... See more keywords
Megalin-Mediated Endocytosis in the Kidney Proximal Tubule: Relevance to Regulation of the Renal Renin-Angiotensin System
Sign Up to like & getrecommendations! Published in 2022 at "Nephron"
DOI: 10.1159/000526369
Abstract: The kidney proximal tubule is a major target tissue of the renin-angiotensin system (RAS). Megalin is an endocytic multiligand receptor abundantly expressed in the proximal tubule where it drives reabsorption of peptides and proteins from… read more here.
Keywords: megalin; tubule; renin angiotensin; kidney proximal ... See more keywords
Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner.
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.12352
Abstract: We have previously shown that podocyte injury increases the glomerular filtration of liver-derived Agt (angiotensinogen) and the generation of intrarenal Ang II (angiotensin II) and that the filtered Agt is reabsorbed by proximal tubules in… read more here.
Keywords: megalin; mice; generation; ang ... See more keywords
Participation of the SMAD2/3 signalling pathway in the down regulation of megalin/LRP2 by transforming growth factor beta (TGF-ß1)
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DOI: 10.1371/journal.pone.0213127
Abstract: Megalin/LRP2 is a receptor that plays important roles in the physiology of several organs, such as kidney, lung, intestine, and gallbladder and also in the physiology of the nervous system. Megalin expression is reduced in… read more here.
Keywords: smad2; transforming growth; tgf; megalin ... See more keywords
Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016060606
Abstract: Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem. Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules, mediates the nephrotoxicity of aminoglycosides and colistin, key antimicrobials for multidrug-resistant… read more here.
Keywords: vancomycin cisplatin; induced nephrotoxicity; cilastatin; megalin ... See more keywords
Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.911664
Abstract: Megalin/LRP2 is the primary multiligand receptor for the re-absorption of low molecular weight proteins in the proximal renal tubule. Its function is significantly dependent on its endosomal trafficking. Megalin recycling from endosomal compartments is altered… read more here.
Keywords: megalin; endosomal trafficking; lowe syndrome; trafficking megalin ... See more keywords