Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
Sign Up to like & getrecommendations! Published in 2017 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2017.02.012
Abstract: Introduction Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a… read more here.
Keywords: expression; tubular expression; megalin cubilin; proximal tubular ... See more keywords
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0510
Abstract: The kidney proximal tubule (PT) elaborates a uniquely high capacity apical endocytic pathway to retrieve albumin and other proteins that escape the glomerular filtration barrier. Megalin and cubilin/amnionless (CUBAM) receptors engage Dab2 in these cells… read more here.
Keywords: megalin; megalin cubilin; endocytic pathway; dab2 ... See more keywords