Preclinical study of the long‐range safety and anti‐inflammatory effects of high‐dose oral meglumine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28492
Abstract: Meglumine is a methylamino derivative of sorbitol that is an approved drug excipient. Recent preclinical studies suggest that administration of high‐dose oral meglumine can exert beneficial medicinal effects to treat diabetes, obesity, and fatty liver… read more here.
Keywords: anti inflammatory; meglumine; high dose; dose oral ... See more keywords
Development and validation of a new HPLC–MS method for meglumine impurity profiling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.11.039
Abstract: ABSTRACT We report a new High Performance Liquid Chromatography‐Mass Spectrometry (HPLC–MS) method to rapidly detect and quantify meglumine by‐products (specifically reducing sugar(s) and nitrogen impurities) that could be present in the meglumine samples. Meglumine is… read more here.
Keywords: validation; meglumine; method; hplc method ... See more keywords
Preclinical pharmacokinetics and tolerability of a novel meglumine‐based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17520
Abstract: For an antiseizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick access to the brain. However, poor aqueous solubility is a major problem in… read more here.
Keywords: status epilepticus; meglumine; topiramate; solution ... See more keywords