Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells.
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2022.04.006
Abstract: OBJECTIVE Ferroptosis is an iron-dependent nonapoptotic form of cell death, characterized by iron accumulation and lipid peroxidation. However, the role of ferroptosis in methylmercury (MeHg)-induced cytotoxicity has yet to be fully characterized. The purpose of… read more here.
Keywords: cytotoxicity; mehg induced; liver; ferroptosis ... See more keywords
Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCĪ“.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.152248
Abstract: Methylmercury (MeHg) is a ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. Curcumin, a polyphenol obtained from the rhizome of turmeric, has well-known antioxidant functions. Here, we evaluated curcumin's efficacy… read more here.
Keywords: curcumin; nrf2 pathway; induced cytotoxicity; mehg induced ... See more keywords
p38/Sp1/Sp4/HDAC4/BDNF Axis Is a Novel Molecular Pathway of the Neurotoxic Effect of the Methylmercury
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2017.00008
Abstract: The molecular pathways involved in methylmercury (MeHg)-induced neurotoxicity are not fully understood. Since pan-Histone deacetylases (HDACs) inhibition has been found to revert the neurodetrimental effect of MeHg, it appeared of interest to investigate whether the… read more here.
Keywords: mehg; hdac4; sp4 hdac4; mehg induced ... See more keywords
Cellular Conditions Responsible for Methylmercury-Mediated Neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137218
Abstract: Methylmercury (MeHg) is a widely known environmental pollutant that causes severe neurotoxicity. MeHg-induced neurotoxicity depends on various cellular conditions, including differences in the characteristics of tissues and cells, exposure age (fetal, childhood, or adulthood), and… read more here.
Keywords: mehg induced; cellular conditions; methylmercury; conditions responsible ... See more keywords
Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies
Sign Up to like & getrecommendations! Published in 2023 at "Toxics"
DOI: 10.3390/toxics11010072
Abstract: MeHg is an environmental neurotoxin that can adversely affect the development of the nervous system. The molecular integrity of chromatin in the nucleus is an important target of MeHg. Low levels of MeHg trigger epigenetic… read more here.
Keywords: mehg induced; dna methylation; methylation mehg; mehg ... See more keywords