Exposure to Mixed Phthalates in Czech Preschool and School Children
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Environmental Contamination and Toxicology"
DOI: 10.1007/s00244-019-00645-6
Abstract: Knowledge of population exposure to phthalates based on the urinary metabolite levels is of the highest importance for health risk assessment. Such data are scarce in the Czech population. In the study conducted in 2016,… read more here.
Keywords: phthalate; butyl phthalate; year olds; mono ... See more keywords
Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-κB signals.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.04.004
Abstract: Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5-10% of cases. There is an urgent need to illustrate risk factors which can trigger the motility of Wilms… read more here.
Keywords: mmp mmp; mmp; mehp; wilms tumor ... See more keywords
Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio).
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.12.094
Abstract: Mono(2-ethylhexyl) phthalate (MEHP) is the bioactive metabolite of di(2-ethylhexyl) phthalate, a plasticizing agent and persistent environmental contaminant associated with obesity, developmental abnormalities, and oxidative stress. Nrf2 (Nfe2l2) is a transcription factor that regulates cytoprotective genes… read more here.
Keywords: mehp; ethylhexyl phthalate; mehp exposure; exposure ... See more keywords
MEHP promotes the proliferation of cervical cancer via GPER mediated activation of Akt
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.01.040
Abstract: &NA; Cervical cancer is the fourth leading cause of cancer death in females worldwide and the second leading cause of mortality among women. Estrogenic signals can regulate the progression of cervical cancer, however, little is… read more here.
Keywords: akt; cervical cancer; gper; activation ... See more keywords
Mono-2-ethylhexyl phthalate drives progression of PINK1-parkin-mediated mitophagy via increasing mitochondrial ROS to exacerbate cytotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101776
Abstract: Phthalate ester plasticizers are used to improve the plasticity and strength of plastics. One of the most widely used and studied, di-2-ethylhexyl phthalate (DEHP), has been labeled as an endocrine disruptor. The major and toxic… read more here.
Keywords: phthalate; mehp cccp; mehp; ethylhexyl phthalate ... See more keywords
In situ Fluorescence Tracking Toxic Metabolite mono-2-ethylhexyl phthalate (MEHP) of di (2-ethylhexyl) phthalate (DEHP) in HeLa Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00191
Abstract: In this study, we synthesized a small molecule fluorescent probe for detecting mono-2-ethylhexyl phthalate (MEHP) named MEHP-AF, which formed by MEHP crosslinked with 5-aminofluorescein (5-AF) through amide bond. MEHP-AF had been purified based on the… read more here.
Keywords: mehp; ethylhexyl phthalate; mono ethylhexyl; phthalate mehp ... See more keywords
Abstract 454: Plasticizer Interaction With the Heart: Chemicals Used in Plastic Medical Devices Can Interfere With Cardiac Electrophysiology
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.454
Abstract: Background: Phthalates are employed as plasticizers in the manufacturing of flexible, plastic medical products. Patients can be subjected to high phthalate exposure through contact with plastic medical devices. We aimed to investigate the cardiac safety… read more here.
Keywords: cardiac electrophysiology; exposure; plastic medical; mehp ... See more keywords
Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23481
Abstract: Phthalates are widely used as plasticizers. Humans can be exposed to phthalates through ingestion, inhalation, or treatments that release di(2-ethylhexyl) phthalate (DEHP) and its metabolite, mono(2-ehylhexyl) phthalate (MEHP), into the body from polyvinyl chloride-based medical… read more here.
Keywords: phthalate exposure; drug; colon cancer; cancer ... See more keywords