Ectopic expression of meiotic cohesin generates chromosome instability in cancer cell line
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204071119
Abstract: Significance This work originated from mining of cancer genome data and proceeded to analyze the effects of ectopic expression of meiotic cohesins in mitotic cells in culture. In the process, apart from conclusively answering the… read more here.
Keywords: ectopic expression; cohesin; expression meiotic; instability ... See more keywords
RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac040
Abstract: Abstract RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis, but the targets and molecular functions of RBM46 remain unknown. Here, we demonstrate that RBM46 binds at specific motifs in the 3ʹUTRs of mRNAs… read more here.
Keywords: gametogenesis; meiotic cohesin; essential gametogenesis; cohesin subunits ... See more keywords
The meiotic cohesin subunit REC8 contributes to multigenic adaptive evolution of autopolyploid meiosis in Arabidopsis arenosa
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010304
Abstract: Genome duplication, which leads to polyploidy, poses challenges to the meiotic segregation of the now-multiple homologous chromosome copies. Genome scan data showed previously that adaptation to polyploid meiosis in autotetraploid Arabidopsis arenosa is likely multigenic,… read more here.
Keywords: rec8; cohesin subunit; meiosis; arenosa ... See more keywords
The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.714245
Abstract: The eukaryotic structural maintenance of chromosomes (SMC) proteins are involved in key processes of chromosome structure and dynamics. SMC1β was identified as a component of the meiotic cohesin complex in vertebrates, which aids in keeping… read more here.
Keywords: meiotic cohesin; cohesin complex; meiosis; smc1b ... See more keywords