Functional organization of protein determinants of meiotic DNA break hotspots
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00742-3
Abstract: During Schizosaccharomyces pombe meiotic prophase, homologous chromosomes are co-aligned by linear elements (LinEs) analogous to the axial elements of the synaptonemal complex (SC) in other organisms. LinE proteins also promote the formation of meiotic DNA… read more here.
Keywords: meiotic dna; protein determinants; line proteins; formation ... See more keywords
Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201454
Abstract: The meiotic DNA break response is shown to involve a large number of phosphorylation changes and a clearly detectable transcriptional response. By contrast, the meiotic proteome remains remarkably unchanged in response to breaks. Meiotic cells… read more here.
Keywords: dna; meiotic dna; dna breaks; dna break ... See more keywords
Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202301906
Abstract: Exchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids. During meiosis, programmed… read more here.
Keywords: dna; meiotic dna; dna exchanges; synaptonemal complex ... See more keywords