Disruption of O‐GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23131
Abstract: Meiotic maturation and fertilization are metabolically demanding processes, and thus the mammalian oocyte is highly susceptible to changes in nutrient availability. O‐GlcNAcylation—the addition of a single sugar residue (O‐linked β‐N‐acetylglucosamine) on proteins—is a posttranslational modification… read more here.
Keywords: fertilization; meiotic maturation; glcnac homeostasis; maturation ... See more keywords
High-dose synthetic phenolic antioxidant propyl gallate impairs mouse oocyte meiotic maturation through inducing mitochondrial dysfunction and DNA damage.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23807
Abstract: Propyl gallate (PG) is one of the most widely used antioxidants in food products, cosmetics and pharmaceutical industries. Increased research has suggested that exposure to PG influences reproductive health in humans and animals. However, until… read more here.
Keywords: oocyte meiotic; meiotic maturation; dna damage; propyl gallate ... See more keywords
Reduced nucleic acid methylation impairs meiotic maturation and developmental potency of pig oocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2018.08.009
Abstract: Oocyte meiosis is a complex process coordinated by multiple endocrinal and molecular circuits. Recently, N6-methyladenosine (m6A) epigenetic modification on RNA is revealed to be important for meiotic maturation. However, the molecular mechanism of how m6A… read more here.
Keywords: meiotic maturation; pig oocytes; m6a; maturation ... See more keywords
Cumulus cell-derived and maternal SIRT6 differentially regulates porcine oocyte meiotic maturation.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.09.048
Abstract: SIRT6, a member of the sirtuin family, is a NAD + dependent protein deacetylase and has been implicated in transcriptional regulation of somatic cells and post-transcriptional regulation of oocyte meiosis. However, the function of cumulus cell-derived and… read more here.
Keywords: cumulus; maternal sirt6; meiotic maturation; cumulus cell ... See more keywords
Mitochondrial E3 ubiquitin ligase MARCH5 is required for mouse oocyte meiotic maturation
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac215
Abstract: Abstract As the most abundant organelles in oocytes, mitochondria play an important role in maintaining oocyte quality. Here, we report that March5, encoding a mitochondrial ubiquitin ligase that promotes mitochondrial elongation, plays a critical role… read more here.
Keywords: maturation; meiotic maturation; mitochondrial ubiquitin; oocyte meiotic ... See more keywords
Spatiotemporal regulation of maternal mRNAs during vertebrate oocyte meiotic maturation
Sign Up to like & getrecommendations! Published in 2023 at "Biological Reviews"
DOI: 10.1111/brv.12937
Abstract: Vertebrate oocytes face a particular challenge concerning the regulation of gene expression during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes, remains halted throughout maturation and fertilization, and only resumes upon embryonic genome… read more here.
Keywords: maturation; meiotic maturation; maternal mrnas; vertebrate ... See more keywords
28: CAN PHTHALATES DISRUPT OOCYTE MEIOTIC MATURATION IN MOUSE MODEL?
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Open"
DOI: 10.1136/bmjopen-2016-015415.28
Abstract: Background and aims: Phthalates, which are commonly used to render plastics into soft and flexible materials, have also determined as developmental and reproductive toxicants in human and animals. The purpose of this study was to… read more here.
Keywords: oocytes retrieved; meiotic maturation; oocyte meiotic; maturation mouse ... See more keywords
Txndc9 Is Required for Meiotic Maturation of Mouse Oocytes
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/6265890
Abstract: Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during… read more here.
Keywords: mouse oocytes; meiotic maturation; maturation mouse; txndc9 ... See more keywords
Bisphenol B Exposure Disrupts Mouse Oocyte Meiotic Maturation in vitro Through Affecting Spindle Assembly and Chromosome Alignment
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.616771
Abstract: Bisphenol B (BPB), a substitute of bisphenol A (BPA), is widely used in the polycarbonate plastic and resins production. However, BPB proved to be not a safe alternative to BPA, and as an endocrine disruptor,… read more here.
Keywords: spindle assembly; chromosome alignment; spindle; meiotic maturation ... See more keywords
High Temperature Disrupts Organelle Distribution and Functions Affecting Meiotic Maturation in Porcine Oocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.826801
Abstract: Heat stress (HS) has been known to cause reproductive failure in animals, especially in summer. HS severely affects the developmental potential of oocytes and leads to low fertility rates. Previous studies have reported that HS… read more here.
Keywords: meiotic maturation; porcine oocytes; maturation porcine; distribution ... See more keywords
Proteomic Exploration of Porcine Oocytes During Meiotic Maturation in vitro Using an Accurate TMT-Based Quantitative Approach
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2021.792869
Abstract: The dynamic changes in protein expression are well known to be required for oocyte meiotic maturation. Although proteomic analysis has been performed in porcine oocytes during in vitro maturation, there is still no full data… read more here.
Keywords: quantitative approach; tmt based; maturation; meiotic maturation ... See more keywords