UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac054
Abstract: Abstract During male meiosis, the constitutively unsynapsed XY chromosomes undergo meiotic sex chromosome inactivation (MSCI), and the DNA damage response (DDR) pathway is critical for MSCI establishment. Our previous study showed that UHRF1 (ubiquitin-like, with… read more here.
Keywords: sex chromosome; chromosome inactivation; sex; meiotic sex ... See more keywords
How oxygen gave rise to eukaryotic sex
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2017.2706
Abstract: How did full meiotic eukaryotic sex evolve and what was the immediate advantage allowing it to develop? We propose that the crucial determinant can be found in internal reactive oxygen species (ROS) formation at the… read more here.
Keywords: oxygen; eukaryotic sex; sex; gave rise ... See more keywords
Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010040
Abstract: During meiotic prophase I, homologous chromosomes pair, synapse and recombine in a tightly regulated process that ensures the generation of genetically variable haploid gametes. Although the mechanisms underlying meiotic cell division have been well studied… read more here.
Keywords: elongation; sex chromosome; meiotic sex; fat tailed ... See more keywords
Genome expansion in early eukaryotes drove the transition from lateral gene transfer to meiotic sex
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.58873
Abstract: Prokaryotes acquire genes from the environment via lateral gene transfer (LGT). Recombination of environmental DNA can prevent the accumulation of deleterious mutations, but LGT was abandoned by the first eukaryotes in favour of sexual reproduction.… read more here.
Keywords: meiotic sex; lateral gene; recombination; gene transfer ... See more keywords