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   Articles with "meis1" as a keyword



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MEIS1 regulated proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.117822

Abstract: AIM Proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) are regarded as the primary factors resulting in pulmonary arterial remodeling in pulmonary hypertension (PH). Myeloid ecotropic viral integration site 1 (MEIS1) has been… read more here.

Keywords: proliferation migration; meis1; migration pasmcs; proliferation ... See more keywords
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Congenital thrombocytopenia associated with a heterozygous variant in the MEIS1 gene encoding a transcription factor essential for megakaryopoiesis

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recommendations! Published in 2022 at "Platelets"

DOI: 10.1080/09537104.2021.1961704

Abstract: Abstract The transcription factor MEIS1 (myeloid ectotrophic insertion site 1) is crucial for the maintenance of hematopoietic stem cells and for megakaryopoiesis. Germline variants in MEIS1 are associated with restless-leg syndrome, but were not previously… read more here.

Keywords: variant meis1; thrombocytopenia associated; thrombocytopenia; transcription factor ... See more keywords
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Reassessing GWAS findings for the shared genetic basis of insomnia and restless legs syndrome

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recommendations! Published in 2018 at "SLEEP"

DOI: 10.1093/sleep/zsy164

Abstract: Two genome-wide association studies (GWAS) suggest that insomnia and restless legs syndrome (RLS) share a common genetic basis. While the identified genetic variation in the MEIS1 gene was previously associated with RLS, the two GWAS… read more here.

Keywords: cid; insomnia restless; insomnia; legs syndrome ... See more keywords
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Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance

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recommendations! Published in 2022 at "Open Biology"

DOI: 10.1098/rsob.220172

Abstract: HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukaemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different… read more here.

Keywords: transgenic zebrafish; acute myeloid; hoxa9; myeloid leukaemia ... See more keywords
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Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc

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recommendations! Published in 2022 at "Haematologica"

DOI: 10.1101/2022.02.03.478956

Abstract: The homeobox transcription factors HoxA9 and Meis1 are causally involved in the etiology of acute myeloid leukemia. While HoxA9 immortalizes cells, cooperation with Meis1 is necessary to induce malignancy. Here, we apply degron techniques to… read more here.

Keywords: myc; stimulation; hoxa9; ribosomal biogenesis ... See more keywords
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MOZ is critical for the development of MOZ/MLL fusion–induced leukemia through regulation of Hoxa9/Meis1 expression

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recommendations! Published in 2022 at "Blood Advances"

DOI: 10.1182/bloodadvances.2020003490

Abstract: Abstract Monocytic leukemia zinc finger protein (MOZ, MYST3, or KAT6A) is a MYST-type acetyltransferase involved in chromosomal translocation in acute myelogenous leukemia (AML) and myelodysplastic syndrome. MOZ is established as essential for hematopoiesis; however, the… read more here.

Keywords: development; moz deficient; moz; moz tif2 ... See more keywords
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Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.

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recommendations! Published in 2022 at "Biomedical research"

DOI: 10.2220/biomedres.43.91

Abstract: Meis1 (myeloid ecotropic insertion site 1) is known to be related to embryonic development and cancer. In this study, to analyze the function of Meis1 in neural stem cells, we crossed Meis1fl/fl (Meis1 floxed) mice… read more here.

Keywords: development regulation; roles cortical; development; cortical development ... See more keywords
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Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli

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recommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2022.901466

Abstract: Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) are necessary for transmitting pain and itch signals. However, the molecular mechanism regulating nociceptor development remains largely unknown. This study identifies that the transcription… read more here.

Keywords: regulates nociceptor; meis1 regulates; nociceptor development; development ... See more keywords
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Dental Epithelial Stem Cells Express the Developmental Regulator Meis1

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recommendations! Published in 2019 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2019.00249

Abstract: MEIS1 is a key developmental regulator of several organs and participates in stem cell maintenance in different niches. However, despite the murine continuously growing incisor being a well described model for the study of adult… read more here.

Keywords: epithelial stem; developmental regulator; dental epithelial; meis1 ... See more keywords