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   Articles with "mek" as a keyword



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Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12186

Abstract: The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50%… read more here.

Keywords: cml; myeloid leukemia; tpl2; resistance ... See more keywords
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MEK/ERK Signaling Regulates Reconstitution of the Dopaminergic Nerve Circuit in the Planarian Dugesia japonica.

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recommendations! Published in 2021 at "Neurochemical research"

DOI: 10.1007/s11064-020-03226-5

Abstract: Planarian Dugesia japonica is a flatworm that can autonomously regenerate its own body after an artificial amputation. A recent report showed the role of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) pathway in the head… read more here.

Keywords: mek erk; dopaminergic neurons; planarian dugesia; regeneration ... See more keywords
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One-pot fabrication of multiporous polymer particles by phase inversion in emulsions

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recommendations! Published in 2017 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"

DOI: 10.1016/j.colsurfa.2017.03.029

Abstract: Abstract Relatively monodisperse spherical poly(styrene-co-acrylonitrile) (SAN) particles may be prepared using phase inversion from water-in-oil (W/O) to oil-in-water (O/W) emulsions containing water-soluble methyl ethyl ketone (MEK) as the oil phase. In this study, we investigate… read more here.

Keywords: phase inversion; inversion; water; san particles ... See more keywords
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Recent developments and obstacles in the treatment of melanoma with BRAF and MEK inhibitors.

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recommendations! Published in 2018 at "Critical reviews in oncology/hematology"

DOI: 10.1016/j.critrevonc.2018.03.005

Abstract: Metastatic melanoma is a least common form of cancer as it accounts only for 1% of all cancer cases. But, it is most deadly in nature and is haunting mankind for long emotionally as well… read more here.

Keywords: melanoma; braf mek; mek inhibitors; mek ... See more keywords
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The Solvent Distribution Effect on the Self-Assembly of Symmetric Triblock Copolymers during Solvent Vapor Annealing

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recommendations! Published in 2018 at "Macromolecules"

DOI: 10.1021/acs.macromol.8b01275

Abstract: Using a combination of systematic experiments and Monte Carlo simulations, this report demonstrates that the distribution of neutral solvent has a strong impact on the quality and kinetics of the self-assembly of block copolymers in… read more here.

Keywords: self assembly; mek; solvent; triblock ... See more keywords
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Divergent effects of intrinsically active MEK variants on developmental Ras signaling

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recommendations! Published in 2017 at "Nature Genetics"

DOI: 10.1038/ng.3780

Abstract: Germline mutations in Ras pathway components are associated with a large class of human developmental abnormalities, known as RASopathies, that are characterized by a range of structural and functional phenotypes, including cardiac defects and neurocognitive… read more here.

Keywords: mek variants; intrinsically active; divergent effects; active mek ... See more keywords
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Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition

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recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2016.486

Abstract: Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six PMMs underwent targeted exome sequencing of 111 cancer-associated genes. Seventy-six somatic nonsynonymous mutations in 42 genes… read more here.

Keywords: inhibition; braf; braf fusion; mucosal melanomas ... See more keywords
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Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma

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recommendations! Published in 2019 at "British Journal of Cancer"

DOI: 10.1038/s41416-019-0673-5

Abstract: Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi) selumetinib or placebo, revealing trends to prolongation of progression-free survival (hazard ratio 0.75, P = 0.130),… read more here.

Keywords: dusp4; response; mek; wild type ... See more keywords
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Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma

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recommendations! Published in 2019 at "Nature Medicine"

DOI: 10.1038/s41591-019-0476-5

Abstract: Oncogene-targeted therapy with B-Raf proto-oncogene (BRAF) and mitogen-activated protein kinase kinase (MEK) inhibitors induces a high initial response rate in patients with BRAFV600-mutated melanoma, with a median duration of response of approximately 1 year1–3. Immunotherapy… read more here.

Keywords: melanoma; braf mek; mek; response ... See more keywords
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Metabolism of inhaled methylethylketone in rats

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recommendations! Published in 2018 at "Drug and Chemical Toxicology"

DOI: 10.1080/01480545.2017.1289220

Abstract: Abstract Methylethylketone (MEK) is widely used in industry, often in combination with other compounds. Although nontoxic, it can make other chemicals harmful. This study investigates the fate of MEK in rat blood, brain and urine… read more here.

Keywords: methylethylketone rats; inhaled methylethylketone; metabolism; metabolism inhaled ... See more keywords
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Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

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recommendations! Published in 2019 at "Platelets"

DOI: 10.1080/09537104.2018.1514107

Abstract: Abstract The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK… read more here.

Keywords: mek inhibitors; platelet dysfunction; mek; platelet ... See more keywords