Inhibition of MEK, a canonical KRAS pathway effector in KRAS mutant NSCLC.
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DOI: 10.21037/tlcr.2018.03.20
Abstract: KRAS mutant NSCLC cells require active nuclear export of Iκβα (also known as NFKBIA), a negative regulatory protein of NF-κB signaling, for maintaining survival signaling (1-3). Nuclear export receptor XPO1 correlates with KRAS mutation status. read more here.
Keywords: inhibition mek; mutant nsclc; canonical kras; kras mutant ... See more keywords