Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.090
Abstract: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 screens in the presence of… read more here.
Keywords: mek inhibition; inhibition; depletion; ras driven ... See more keywords
Effect of MEK inhibition on PDL1 and and on cytokinesproduction profilein NSCLC cell lines and in human lymphocites: 51PD
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/s1556-0864(18)30328-9
Abstract: Background: Preclinical models suggest that MAPK pathway is implicated in the immune-resistance of tumors and MEK-inhibition can increase the CD8+ T-cell infiltration and the efficacy of PD-1/PD-L1 blockade. Methods: First, we evaluated PD-L1 mRNA expression… read more here.
Keywords: cell lines; inhibition; mek inhibition; expression ... See more keywords
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00728-9
Abstract: The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can… read more here.
Keywords: following mek; infiltrating lymphocytes; mek inhibition; inhibition ... See more keywords
Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67814-9
Abstract: Pancreatic cancer, one of the deadliest human malignancies, has a dismal 5-year survival rate of 9%. KRAS is the most commonly mutated gene in pancreatic cancer, but clinical agents that directly target mutant KRAS are… read more here.
Keywords: integrin signaling; mek inhibition; inhibition; pancreatic cancer ... See more keywords
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.01.10.475285
Abstract: Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma – namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies – may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still,… read more here.
Keywords: presentation; mek inhibition; tumor antigens; tumor ... See more keywords
MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau0417
Abstract: Combining oncolytic virus and a MEK inhibitor augments immune-mediated therapeutic responses in melanoma and enhances sensitivity to PD-1 blockade in mice. Enabling immunotherapy with an oncolytic virus Immunotherapy treatments have been pioneered in the setting… read more here.
Keywords: oncolytic virus; immunotherapy; mek inhibition; cell ... See more keywords
MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells International"
DOI: 10.1155/2019/8475389
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related… read more here.
Keywords: cancer stem; mek inhibition; pancreatic cancer; cancer cells ... See more keywords
Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-3792
Abstract: This study demonstrates the critical role of glucose metabolism in resistance to MAPK inhibition in KRAS-driven pancreatic cancer, uncovering a potential therapeutic approach for treating this aggressive disease. Pancreatic ductal adenocarcinoma (PDAC) is almost universally… read more here.
Keywords: pdac; cancer; mek inhibition; glucose metabolism ... See more keywords
MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-22-3722
Abstract: Abstract Purpose: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. About half of MPNST cases are associated with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome.… read more here.
Keywords: nerve sheath; sheath tumors; malignant peripheral; inhibition ... See more keywords
Abstract A121: Adaptive and acquired signaling response to MEK inhibition in NF1-associated malignant peripheral nerve sheath tumor
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a121
Abstract: Background: About 50% of MPNST arise in patients with neurofibromatosis type 1, and these tumors are among the most difficult types of soft tissue sarcoma to manage. NF1 is a tumor suppressor gene essential for… read more here.
Keywords: resistance; tumor; mek inhibition; meki ... See more keywords
Abstract 4095: Active Kras induced metaplasia progression toward gastric neoplasia is suppressed by MEK inhibition during gastric carcinogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4095
Abstract: Intestinal type gastric cancer develops within metaplastic mucosal fields and development of gastric neoplasia represents the most prominent example of gastric cancer developing within the morphologic changes of metaplasia. Recent investigations have noted activation of… read more here.
Keywords: gastric neoplasia; mek inhibition; active kras; cancer ... See more keywords