MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12102
Abstract: Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors.… read more here.
Keywords: erk; mek inhibitors; akt activation; activation ... See more keywords
Neurofibromatosis in the Era of Precision Medicine: Development of MEK Inhibitors and Recent Successes with Selumetinib
Sign Up to like & getrecommendations! Published in 2021 at "Current Oncology Reports"
DOI: 10.1007/s11912-021-01032-y
Abstract: Patients with neurofibromatosis type 1 (NF1) are at increased risk for benign and malignant neoplasms. Recently, targeted therapy with the MEK inhibitor class has helped address these needs. We highlight recent successes with selumetinib while… read more here.
Keywords: medicine; mek inhibitors; successes selumetinib; recent successes ... See more keywords
Cardiac Effects of BRAF and MEK Inhibitors: Mechanisms and Clinical Management
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-022-01205-3
Abstract: Purpose of Review The identification of BRAF mutation prompted the development of new class of targeted therapy for treating melanoma: BRAF inhibitors and MEK inhibitors. Cardiovascular events have been reported with these treatments and could… read more here.
Keywords: oncology; braf mek; mek inhibitors; management ... See more keywords
Sarcoidosis related to checkpoint and BRAF/MEK inhibitors in melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2020.102587
Abstract: Therapy for advanced melanoma has deeply changed in the last decade with the introduction of checkpoint and BRAF/MEK inhibitors. Granulomatous reactions have been reported related to these drugs. We performed a systematic review of all… read more here.
Keywords: braf mek; checkpoint braf; mek inhibitors; sarcoidosis ... See more keywords
Recent developments and obstacles in the treatment of melanoma with BRAF and MEK inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2018.03.005
Abstract: Metastatic melanoma is a least common form of cancer as it accounts only for 1% of all cancer cases. But, it is most deadly in nature and is haunting mankind for long emotionally as well… read more here.
Keywords: melanoma; braf mek; mek inhibitors; mek ... See more keywords
Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02077-w
Abstract: Targeting the KRAS pathway is a promising but challenging approach for colorectal cancer therapy. Despite showing potent efficacy in BRAF-mutated melanoma, MEK inhibitors appeared to be tolerated by colorectal cancer cells due to their intrinsic… read more here.
Keywords: genome wide; plk1; mek inhibitor; mek inhibitors ... See more keywords
Cardiotoxicity in metastatic melanoma patients treated with BRAF and MEK inhibitors in a real-world setting
Sign Up to like & getrecommendations! Published in 2021 at "Acta Oncologica"
DOI: 10.1080/0284186x.2021.1992010
Abstract: Abstract Background Combination therapy with BRAF and MEK inhibitors (BRAF/MEKi) has significantly improved the outcome for patients with BRAF-mutated melanoma. A reduction in left ventricular ejection fraction (LVEF) is a known side effect during treatment… read more here.
Keywords: mek inhibitors; lvef; braf mek; braf meki ... See more keywords
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Platelets"
DOI: 10.1080/09537104.2018.1514107
Abstract: Abstract The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK… read more here.
Keywords: mek inhibitors; platelet dysfunction; mek; platelet ... See more keywords
Truth or dare: switching BRAF/MEK inhibitors after acute interstitial nephritis in a patient with metastatic melanoma – A case report and review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Acta Clinica Belgica"
DOI: 10.1080/17843286.2022.2114684
Abstract: ABSTRACT Introduction The introduction of BRAF/MEK inhibitors has significantly improved overall survival of patients with BRAF V600-mutant advanced or metastatic melanoma. Most patients treated with BRAF/MEK inhibitors will experience adverse events during the course of… read more here.
Keywords: interstitial nephritis; mek inhibitors; mek; braf mek ... See more keywords
BRAF and MEK inhibitors differentially affect nivolumab-induced T cell activation by modulating the TCR and AKT signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1512456
Abstract: ABSTRACT Immune checkpoint inhibitors (ICIs) such as the anti-PD-1 antibody Nivolumab, achieve remarkable clinical efficacy in patients with late stage cancers. However, only a small subset of patients benefit from this therapy. Numerous clinical trials… read more here.
Keywords: mek inhibitors; induced cell; cell activation; cell ... See more keywords
EXTH-08. MINIPIG MODELS OF NEUROFIBROMATOSIS TYPE 1 FOR THERAPEUTIC DEVELOPMENT
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.362
Abstract: Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in the neurofibromin 1 (NF1) gene. NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development. Many NF1 animal… read more here.
Keywords: exth minipig; minipig; mek inhibitors; neurofibromatosis type ... See more keywords